GDE1

GDE1, also known as MIR16, as a broadly expressed membrane enzyme with robust GP-NAE phosphodiesterase activity.

Full Name

GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1

Function

Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity).

Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and partipates to bioactive N-acylethanolamines biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity).

Has little or no activity towards glycerophosphocholine (By similarity).

Biological Process

Ethanolamine metabolic process Source: UniProtKB
Glycerophospholipid catabolic process Source: Reactome
Lipid metabolic process Source: UniProtKB
N-acylethanolamine metabolic process Source: UniProtKB
Phospholipid metabolic process Source: UniProtKB

Cellular Location

Cell membrane; Cytoplasmic vesicle membrane. Perinuclear vesicles and cell membrane.

Topology

Cytoplasmic: 1-3
Helical: 4-24
Lumenal: 25-247
Helical: 248-268
Cytoplasmic: 269-331

PTM

N-glycosylated.