GDE1

GDE1, also known as MIR16, as a broadly expressed membrane enzyme with robust GP-NAE phosphodiesterase activity.
Full Name
GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1
Function
Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity).

Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and partipates to bioactive N-acylethanolamines biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity).

Has little or no activity towards glycerophosphocholine (By similarity).
Biological Process
Ethanolamine metabolic process Source: UniProtKB
Glycerophospholipid catabolic process Source: Reactome
Lipid metabolic process Source: UniProtKB
N-acylethanolamine metabolic process Source: UniProtKB
Phospholipid metabolic process Source: UniProtKB
Cellular Location
Cell membrane; Cytoplasmic vesicle membrane. Perinuclear vesicles and cell membrane.
Topology
Cytoplasmic: 1-3
Helical: 4-24
Lumenal: 25-247
Helical: 248-268
Cytoplasmic: 269-331
PTM
N-glycosylated.
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Anti-GDE1 antibodies

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Mouse Anti-GDE1 Recombinant Antibody (2H6) (CBMAB-A5488-LY)

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Target: GDE1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2H6
Application*: IF, E
Datasheet SDS

Mouse Anti-GDE1 Recombinant Antibody (CBLG1-823) (CBMAB-G2692-LY)

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Target: GDE1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-823
Application*: E
Datasheet SDS

Mouse Anti-GDE1 Recombinant Antibody (2H6) (CBMAB-G2691-LY)

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Target: GDE1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2H6
Application*: E, IC, IF
Datasheet SDS

Mouse Anti-GDE1 Recombinant Antibody (CBLG1-823) (V2LY-1225-LY969)

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Target: GDE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-823
Application*: WB
Datasheet SDS

Mouse Anti-GDE1 Recombinant Antibody (2H6) (V2LY-1225-LY968)

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Target: GDE1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2H6
Application*: E, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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