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GDE1

GDE1, also known as MIR16, as a broadly expressed membrane enzyme with robust GP-NAE phosphodiesterase activity.

Full Name

GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1

Function

Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity).

Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and partipates to bioactive N-acylethanolamines biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity).

Has little or no activity towards glycerophosphocholine (By similarity).

Biological Process

Ethanolamine metabolic process Source: UniProtKB
Glycerophospholipid catabolic process Source: Reactome
Lipid metabolic process Source: UniProtKB
N-acylethanolamine metabolic process Source: UniProtKB
Phospholipid metabolic process Source: UniProtKB

Cellular Location

Cell membrane; Cytoplasmic vesicle membrane. Perinuclear vesicles and cell membrane.

Topology

Cytoplasmic: 1-3
Helical: 4-24
Lumenal: 25-247
Helical: 248-268
Cytoplasmic: 269-331

PTM

N-glycosylated.

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Anti-GDE1 antibodies

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Mouse Anti-GDE1 Recombinant Antibody (2H6) (CBMAB-A5488-LY)

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Target: GDE1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2H6

Application*: IF, E

Mouse Anti-GDE1 Recombinant Antibody (CBLG1-823) (CBMAB-G2692-LY)

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Target: GDE1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBLG1-823

Application*: E

Mouse Anti-GDE1 Recombinant Antibody (2H6) (CBMAB-G2691-LY)

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Target: GDE1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2H6

Application*: E, IC, IF

Mouse Anti-GDE1 Recombinant Antibody (CBLG1-823) (V2LY-1225-LY969)

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Target: GDE1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-823

Application*: WB

Mouse Anti-GDE1 Recombinant Antibody (2H6) (V2LY-1225-LY968)

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Target: GDE1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2H6

Application*: E, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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