GNL3L

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Full Name

G Protein Nucleolar 3 Like

Function

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

Biological Process

Negative regulation of protein binding Source: BHF-UCL
Negative regulation of protein sumoylation Source: BHF-UCL
Negative regulation of protein ubiquitination Source: BHF-UCL
Negative regulation of telomere maintenance via telomerase Source: BHF-UCL
Positive regulation of protein-containing complex assembly Source: BHF-UCL
Positive regulation of protein localization to chromosome, telomeric region Source: BHF-UCL
Regulation of protein stability Source: BHF-UCL
Ribosome biogenesis Source: UniProtKB-KW

Cellular Location

Nucleolus