Rabbit Anti-GNL3L Recombinant Antibody (EG1343) (CBMAB-EN1621-LY)

Name: Rabbit Anti-GNL3L Recombinant Antibody (EG1343)
SKU: CBMAB-EN1621-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1343

Application

WB: 1:500~1:1000 ELISA: 1:5000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GNL3L.

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

G Protein Nucleolar 3 Like

Introduction

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Entrez Gene ID

54552

UniProt ID

Q9NVN8

Alternative Names

G Protein Nucleolar 3 Like; Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like; G Protein Nucleolar 3B; Guanine Nucleotide-Binding Protein-Like 3-Like Protein; Novel GTPase; EC 3.6.1; GNL3B;

Function

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

Biological Process

Negative regulation of protein binding Source: BHF-UCL
Negative regulation of protein sumoylation Source: BHF-UCL
Negative regulation of protein ubiquitination Source: BHF-UCL
Negative regulation of telomere maintenance via telomerase Source: BHF-UCL
Positive regulation of protein-containing complex assembly Source: BHF-UCL
Positive regulation of protein localization to chromosome, telomeric region Source: BHF-UCL
Regulation of protein stability Source: BHF-UCL
Ribosome biogenesis Source: UniProtKB-KW

Cellular Location

Nucleolus

Liu, P., Guo, W., Su, Y., Chen, C., Ma, Y., Ma, P., ... & Lv, X. (2022). Multi-Omics Analysis of GNL3L Expression, Prognosis, and Immune Value in Pan-Cancer. Cancers, 14(19), 4595.

Kannathasan, T., Kuo, W. W., Chen, M. C., Viswanadha, V. P., Shen, C. Y., Tu, C. C., ... & Huang, C. Y. (2020). Chemoresistance-associated silencing of miR-4454 promotes colorectal cancer aggression through the GNL3L and NF-κB pathway. Cancers, 12(5), 1231.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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