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Rabbit Anti-GNL3L Recombinant Antibody (EG1343) (CBMAB-EN1621-LY)

The product is antibody recognizes GNL3L. The antibody EG1343 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:5000.
See all GNL3L antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1343
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:5000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GNL3L.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein Nucleolar 3 Like
Introduction
The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
Entrez Gene ID
54552
UniProt ID
Q9NVN8
Alternative Names
G Protein Nucleolar 3 Like; Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like; G Protein Nucleolar 3B; Guanine Nucleotide-Binding Protein-Like 3-Like Protein; Novel GTPase; EC 3.6.1; GNL3B;
Function
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Biological Process
Negative regulation of protein binding Source: BHF-UCL
Negative regulation of protein sumoylation Source: BHF-UCL
Negative regulation of protein ubiquitination Source: BHF-UCL
Negative regulation of telomere maintenance via telomerase Source: BHF-UCL
Positive regulation of protein-containing complex assembly Source: BHF-UCL
Positive regulation of protein localization to chromosome, telomeric region Source: BHF-UCL
Regulation of protein stability Source: BHF-UCL
Ribosome biogenesis Source: UniProtKB-KW
Cellular Location
Nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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