GPR174

This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]

Full Name

G Protein-Coupled Receptor 174

Function

Putative receptor for purines coupled to G-proteins.

Biological Process

Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of Rho protein signal transduction Source: GO_Central
T cell homeostasis Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-27
Helical: 28-48
Cytoplasmic: 49-53
Helical: 54-74
Extracellular: 75-91
Helical: 92-112
Cytoplasmic: 113-134
Helical: 135-155
Extracellular: 156-182
Helical: 183-203
Cytoplasmic: 204-231
Helical: 232-252
Extracellular: 253-269
Helical: 270-290
Cytoplasmic: 291-333