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Rabbit Anti-GPR174 Recombinant Antibody (EG1393) (CBMAB-EN1672-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1393
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GPR174.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein-Coupled Receptor 174
Introduction
This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]
Entrez Gene ID
84636
UniProt ID
Q9BXC1
Alternative Names
G Protein-Coupled Receptor 174; Probable G-Protein Coupled Receptor 174; FKSG79; GPCR17; LYPSR3;
Function
Putative receptor for purines coupled to G-proteins.
Biological Process
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of Rho protein signal transduction Source: GO_Central
T cell homeostasis Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-27
Helical: 28-48
Cytoplasmic: 49-53
Helical: 54-74
Extracellular: 75-91
Helical: 92-112
Cytoplasmic: 113-134
Helical: 135-155
Extracellular: 156-182
Helical: 183-203
Cytoplasmic: 204-231
Helical: 232-252
Extracellular: 253-269
Helical: 270-290
Cytoplasmic: 291-333
More Infomation

Liu, J., Pan, L., Hong, W., Chen, S., Bai, P., Luo, W., ... & Sun, A. (2022). GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression. Nature Communications, 13(1), 7519.

Wang, J., Hu, Y., Kuang, Z., Chen, Y., Xing, L., Wei, W., ... & Song, Z. (2022). GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With Sepsis via Regulating the Inflammatory Response. Frontiers in Immunology, 12, 5605.

Yue, J., & Zhao, X. (2020). GPR174 suppression attenuates retinopathy in angiotensin II (Ang II)-treated mice by reducing inflammation via PI3K/AKT signaling. Biomedicine & Pharmacotherapy, 122, 109701.

Cho, W. K., Shin, H. R., Lee, N. Y., Kim, S. K., Ahn, M. B., Baek, I. C., ... & Suh, B. K. (2020). GPR174 and ITM2A Gene Polymorphisms rs3827440 and rs5912838 on the X chromosome in Korean Children with Autoimmune Thyroid Disease. Genes, 11(8), 858.

Qiu, D., Chu, X., Hua, L., Yang, Y., Li, K., Han, Y., ... & Song, Z. (2019). Gpr174-deficient regulatory T cells decrease cytokine storm in septic mice. Cell Death & Disease, 10(3), 233.

Hwang, S. M., Kim, H. J., Kim, S. M., Jung, Y., Park, S. W., & Chung, I. Y. (2018). Lysophosphatidylserine receptor P2Y10: AG protein‐coupled receptor that mediates eosinophil degranulation. Clinical & Experimental Allergy, 48(8), 990-999.

Barnes, M. J., & Cyster, J. G. (2018). Lysophosphatidylserine suppression of T‐cell activation via GPR 174 requires Gαs proteins. Immunology and cell biology, 96(4), 439-445.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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