GSDMC

The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores.

Full Name

gasdermin C

Function

Gasdermin-C:
This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death.

Gasdermin-C, N-terminal:
Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:27281216).

Released upon cleavage and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (By similarity).

The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (Probable).

Biological Process

Defense response to bacterium Source: GO_Central
Pyroptosis Source: GO_Central

Cellular Location

Gasdermin-C: Cytosol
Gasdermin-C, N-terminal: Cell membrane

PTM

Cleavage relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-C, N-terminal) that initiates pyroptosis.