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Rabbit Anti-GSDMC Recombinant Antibody (EG1456) (CBMAB-EN1737-LY)

The product is antibody recognizes GSDMC. The antibody EG1456 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all GSDMC antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1456
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GSDMC.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
gasdermin C
Entrez Gene ID
56169
UniProt ID
Q9BYG8
Alternative Names
MLZE
Function
Gasdermin-C:
This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death.

Gasdermin-C, N-terminal:
Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:27281216).

Released upon cleavage and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (By similarity).

The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (Probable).
Biological Process
Defense response to bacterium Source: GO_Central
Pyroptosis Source: GO_Central
Cellular Location
Gasdermin-C: Cytosol
Gasdermin-C, N-terminal: Cell membrane
PTM
Cleavage relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-C, N-terminal) that initiates pyroptosis.

Du, J., Sarkar, R., Li, Y., He, L., Kang, W., Liao, W., ... & Li, Y. C. (2022). N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis. Developmental Cell, 57(16), 1976-1994.

Yan, C., Niu, Y., Li, F., Zhao, W., & Ma, L. (2022). System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma. Journal of Translational Medicine, 20(1), 1-19.

Li, Z., Gu, L., Gao, Q., Li, L., Sheng, M., Ling, Y., ... & Chen, M. (2022). Mechanism investigation of Caspase-8/GSDMC dependent immunogenic cell death induced by Ophiopogonin B in NSCLC cells. Pharmacological Research-Modern Chinese Medicine, 4, 100157.

Lie, M. U., Pedersen, L. M., Heuch, I., Winsvold, B., Gjerstad, J., Hasvik, E., ... & Nilsen, K. B. (2022). Low back pain with persistent radiculopathy; the clinical role of genetic variants in the genes SOX5, CCDC26/GSDMC and DCC. Frontiers in Genetics, 12, 2887.

Zhang, J. Y., Zhou, B., Sun, R. Y., Ai, Y. L., Cheng, K., Li, F. N., ... & Wu, Q. (2021). The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Cell research, 31(9), 980-997.

Cui, Y. Q., Meng, F., Zhan, W. L., Dai, Z. T., & Liao, X. (2021). High expression of GSDMC is associated with poor survival in kidney clear cell cancer. BioMed Research International, 2021.

Wei, J., Xu, Z., Chen, X., Wang, X., Zeng, S., Qian, L., ... & Yan, Y. (2020). Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma. Molecular medicine reports, 21(1), 360-370.

Wu, J., Sun, Y., Xiong, Z., Liu, J., Li, H., Liu, Y., ... & Jin, T. (2020). Association of GSDMC polymorphisms with lumbar disc herniation among Chinese Han population. International Journal of Immunogenetics, 47(6), 546-553.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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