GUK1

The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.
Full Name
guanylate kinase 1
Function
Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273).

Involved in the cGMP metabolism in photoreceptors (By similarity).

It may also have a role in the survival and growth progression of some tumors (PubMed:31201273).

In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664).
Biological Process
dGDP biosynthetic process Source: UniProtKB
Nucleobase-containing small molecule interconversion Source: Reactome
Purine nucleotide metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: UniProtKB
Cellular Location
Cytosol; Photoreceptor inner segment. Colocalizes with RD3 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer.
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Anti-GUK1 antibodies

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Mouse Anti-GUK1 Recombinant Antibody (CBLG1-3048) (CBMAB-G5807-LY)

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Target: GUK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-3048
Application*: WB
Datasheet SDS

Mouse Anti-GUK1 Recombinant Antibody (4C3-1A7) (CBMAB-G5806-LY)

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Target: GUK1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4C3-1A7
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-GUK1 Recombinant Antibody (4A8) (CBMAB-G5805-LY)

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Target: GUK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4A8
Application*: F
Datasheet SDS

Mouse Anti-GUK1 Recombinant Antibody (1H3) (CBMAB-G5804-LY)

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Target: GUK1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: 1H3
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-GUK1 Recombinant Antibody (1D7) (CBMAB-G5803-LY)

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Target: GUK1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1D7
Application*: F
Datasheet SDS

Mouse Anti-GUK1 Recombinant Antibody (CBFYH-0544) (CBMAB-H1423-FY)

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Target: GUK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0544
Application*: F
Datasheet SDS

Mouse Anti-GUK1 (AA 1-197) Recombinant Antibody (CBFYH-0543) (CBMAB-H1422-FY)

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Target: GUK1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0543
Application*: E, WB
Datasheet SDS

Mouse Anti-GUK1 Recombinant Antibody (CBFYH-0542) (CBMAB-H1421-FY)

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Target: GUK1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0542
Application*: F, IH, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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