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Mouse Anti-GUK1 (AA 1-197) Recombinant Antibody (CBFYH-0543) (CBMAB-H1422-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0543
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-197

Target

Full Name
guanylate kinase 1
Introduction
The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
2987
UniProt ID
Q16774
Alternative Names
Guanylate Kinase 1; GMP Kinase; EC 2.7.4.8; GMK; ATP:GMP Phosphotransferase; Guanylate Kinase
Function
Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273).

Involved in the cGMP metabolism in photoreceptors (By similarity).

It may also have a role in the survival and growth progression of some tumors (PubMed:31201273).

In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664).
Biological Process
dGDP biosynthetic process Source: UniProtKB
Nucleobase-containing small molecule interconversion Source: Reactome
Purine nucleotide metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: UniProtKB
Cellular Location
Cytosol; Photoreceptor inner segment. Colocalizes with RD3 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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