Mouse Anti-GUK1 Recombinant Antibody (CBFYH-0542) (CBMAB-H1421-FY)

Name: Mouse Anti-GUK1 Recombinant Antibody (CBFYH-0542)
SKU: CBMAB-H1421-FY
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBFYH-0542

Application

FC, IHC, WB

Immunogen

Full length recombinant protein of human GUK1 produced in HEK293T cells

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

guanylate kinase 1

Introduction

The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

2987

UniProt ID

Q16774

Alternative Names

Guanylate Kinase 1; GMP Kinase; EC 2.7.4.8; GMK; ATP:GMP Phosphotransferase; Guanylate Kinase

Function

Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273).

Involved in the cGMP metabolism in photoreceptors (By similarity).

It may also have a role in the survival and growth progression of some tumors (PubMed:31201273).

In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664).

Biological Process

dGDP biosynthetic process Source: UniProtKB
Nucleobase-containing small molecule interconversion Source: Reactome
Purine nucleotide metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: UniProtKB

Cellular Location

Cytosol; Photoreceptor inner segment. Colocalizes with RD3 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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