H1FX

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family.

Full Name

H1 Histone Family Member X

Function

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.

Biological Process

Chromosome condensation Source: GO_Central
Negative regulation of DNA recombination Source: GO_Central
Nucleosome assembly Source: InterPro
Nucleosome positioning Source: GO_Central

Cellular Location

Nucleus; Chromosome

PTM

Citrullination at Arg-62 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.