KCNAB1

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits.

Full Name

Potassium Voltage-Gated Channel Subfamily A Member Regulatory Beta Subunit 1

Function

Function
Function
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757).
Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity).
Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity).
Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623).
Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757).
Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623).
Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368).
Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity).
Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764).
Enhances KCNB1 and KCNB2 channel activity (By similarity).
Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341).
Has NADPH-dependent aldoketoreductase activity (By similarity).
Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).

Biological Process

Negative regulation of delayed rectifier potassium channel activityManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of voltage-gated potassium channel activityManual Assertion Based On ExperimentIMP:CAFA
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Regulation of delayed rectifier potassium channel activityISS:UniProtKB
Regulation of potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm; Membrane; Cell membrane. Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits.