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LRP1

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
Full Name
LRP1
Function
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657).
Required for early embryonic development (By similarity).
Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:26142438, PubMed:1702392).
Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178).
May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553).
(Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
Biological Process
Amyloid-beta clearanceManual Assertion Based On ExperimentTAS:BHF-UCL
Amyloid-beta clearance by cellular catabolic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Amyloid-beta clearance by transcytosisManual Assertion Based On ExperimentIGI:ARUK-UCL
Aorta morphogenesisISS:BHF-UCL
Apoptotic cell clearanceISS:BHF-UCL
Astrocyte activation involved in immune responseISS:ARUK-UCL
Cellular response to amyloid-betaISS:ARUK-UCL
Enzyme linked receptor protein signaling pathwayBy SimilarityISS:BHF-UCL
Lipid metabolic processManual Assertion Based On ExperimentTAS:ARUK-UCL
Lipoprotein transport1 PublicationNAS:UniProtKB
Lysosomal transportISS:UniProtKB
Negative regulation of gene expressionBy SimilarityISS:BHF-UCL
Negative regulation of metallopeptidase activity1 PublicationIC:ARUK-UCL
Negative regulation of pathway-restricted SMAD protein phosphorylationBy SimilarityISS:BHF-UCL
Negative regulation of platelet-derived growth factor receptor-beta signaling pathwayISS:BHF-UCL
Negative regulation of SMAD protein signal transductionBy SimilarityISS:BHF-UCL
Negative regulation of smooth muscle cell migrationISS:BHF-UCL
Negative regulation of Wnt signaling pathwayISS:BHF-UCL
PhagocytosisManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of amyloid-beta clearanceISS:ARUK-UCL
Positive regulation of cell deathManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of cholesterol effluxISS:BHF-UCL
Positive regulation of endocytosisManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of lipid transportISS:BHF-UCL
Positive regulation of lysosomal protein catabolic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of protein bindingManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of transcytosisISS:ARUK-UCL
Receptor internalizationManual Assertion Based On ExperimentIDA:ComplexPortal
Receptor-mediated endocytosisManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of actin cytoskeleton organizationISS:BHF-UCL
Regulation of cholesterol transportISS:BHF-UCL
Regulation of extracellular matrix disassemblyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Regulation of phospholipase A2 activityISS:BHF-UCL
Retinoid metabolic processTAS:Reactome
TranscytosisManual Assertion Based On ExperimentTAS:ARUK-UCL
Transport across blood-brain barrierISS:ARUK-UCL
Cellular Location
Low-density lipoprotein receptor-related protein 1 85 kDa subunit:
Cell membrane
Membrane, coated pit
Low-density lipoprotein receptor-related protein 1 515 kDa subunit:
Cell membrane ; Peripheral membrane protein
Membrane, coated pit
Low-density lipoprotein receptor-related protein 1 intracellular domain:
Cytoplasm
Nucleus
After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
Golgi outpost
Cytoplasm, cytoskeleton, microtubule organizing center
Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation.
Involvement in disease
Keratosis pilaris atrophicans (KPA):
A group of rare genodermatoses characterized by keratotic follicular papules, variable degrees of inflammation, and secondary atrophic scarring. Most cases are associated with an atopic diathesis and keratosis pilaris on the extensor extremities. KPA is comprised of three distinct clinical subtypes: keratosis pilaris atrophicans faciei, atrophoderma vermiculatum, and keratosis follicularis spinulosa decalvans. Affected individuals may present with features overlapping the 3 subtypes.
Topology
Extracellular: 20-4419
Helical: 4420-4444
Cytoplasmic: 4445-4544
PTM
Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.
The N-terminus is blocked.
Phosphorylated on serine and threonine residues.
Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.

Anti-LRP1 antibodies

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Target: LRP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4125
Application*: WB, IH, F
Target: LRP1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0916
Application*: F
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2645
Application*: C, IF, WB, F
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2643
Application*: E, F, IF, IH, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2641
Application*: E, F, IF, IH, IP, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F142
Application*: IH, F
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0148
Application*: E, F, IH, IP, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: CBFYM-1224
Application*: F, P, IF, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8G1
Application*: B, EM, F
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: 8B8
Application*: F
Target: LRP1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 2C6
Application*: B, IP, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rabbit
Clone: CBFYM-1223
Application*: E, F, IC, IF, C, P, WB, IP
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-1222
Application*: DB, MS, F, C, P, IF, WB, BL
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-2423
Application*: DB, EM, F, IH, IF, WB, BL
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: CBXF-2425
Application*: F, P, IF, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1967
Application*: E, C, P, IP, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MA-8B8
Application*: F, C, P, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: MA-5A6
Application*: F, P, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJL-1965
Application*: E, F, C, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A2Mr alpha-2
Application*: F
Target: LRP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5A6
Application*: IC, IF
Target: LRP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1964
Application*: WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Dog, Rabbit
Clone: CBYJL-1963
Application*: WB, IF, IH, IP
Target: LRP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1C8G6
Application*: WB, F, E, IH
Target: LRP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYJL-1962
Application*: WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBYJL-1961
Application*: F, IH, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1960
Application*: F, IH, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 11D42
Application*: E, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1959
Application*: E, F, IH, IP, WB
Target: LRP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A935
Application*: FC, ICC, IF, IHC, IP, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: A934
Application*: IHC, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A933
Application*: FC, IF, IHC, WB
Target: LRP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A932
Application*: FC, ICC, IF, IHC, IP, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A931
Application*: ELISA, FC, IB, IF
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Hamster, Human, Mouse, Rabbit, Rat
Clone: A930
Application*: FC, ICC, IF, IHC, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Hamster, Human, Mouse, Rabbit, Rat
Clone: A929
Application*: ELISA, FC, IB, IF
Target: LRP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb155
Application*: WB, IH, IF, IP
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: n.a
Application*: C, E, IP, P, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNC-656
Application*: FC, IH, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-655
Application*: IH, E, IP, P, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4H306
Application*: FC, IF, IH, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6A34
Application*: E, F, IF, C, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rabbit
Clone: 5F140
Application*: F, C, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rabbit
Clone: 5F126
Application*: F, C, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1760
Application*: E, F, IF, IH, IP, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1766
Application*: E, F, IH, IP, WB
Target: LRP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCL-465
Application*: WB, P, IF, IC, IP, F
Target: LRP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rabbit
Clone: CBYCL-464
Application*: F, P, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYCL-463
Application*: F, IF, IH, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-462
Application*: E, IF, IH, IP, WB
Target: LRP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rabbit
Clone: CBYCL-461
Application*: WB, P
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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