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MBD2

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Anti-MBD2 antibodies

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Mouse Anti-MBD2 Recombinant Antibody (CBFYM-1799) (CBMAB-M1967-FY)

Target: MBD2
Host: Mouse
Cross Reactivity: Mouse, Rat, Human
Clone: CBFYM-1799
Application*: WB, IP, IF, P, E

Mouse Anti-MBD2 Recombinant Antibody (1B6) (CBMAB-0638-YC)

Target: MBD2
Host: Mouse
Antibody Isotype: IgG2a
Cross Reactivity: Human
Clone: 1B6
Application*: E, IP

Rabbit Anti-MBD2 Recombinant Antibody (CBFYM-1800) (CBMAB-M1968-FY)

Target: MBD2
Host: Rabbit
Antibody Isotype: IgG
Cross Reactivity: Mouse, Rat, Human
Clone: CBFYM-1800
Application*: WB, IP, P, IF

Mouse Anti-MBD2 Recombinant Antibody (CBDH1714) (CBMAB-DH1714-LY)

Target: MBD2
Host: Mouse
Antibody Isotype: IgG2a
Cross Reactivity: Human
Clone: CBDH1714
Application*: ELISA, IP
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)