MFRP

This gene encodes a member of the frizzled-related proteins. The encoded protein may play a role in eye development, as mutations in this gene have been associated with nanophthalmos, posterior microphthalmia, retinitis pigmentosa, foveoschisis, and optic disc drusen. The protein is encoded by a bicistronic mRNA, which also encodes C1q and tumor necrosis factor related protein 5
Full Name
membrane frizzled-related protein
Function
May play a role in eye development.
Biological Process
Embryo development ending in birth or egg hatching Source: UniProtKB
Eye photoreceptor cell development Source: Ensembl
Retina development in camera-type eye Source: Ensembl
Visual perception Source: Ensembl
Cellular Location
Apical cell membrane
Involvement in disease
Nanophthalmos 2 (NNO2):
Rare autosomal recessive disorder of eye development characterized by extreme hyperopia and small functional eyes.
Microphthalmia, isolated, 5 (MCOP5):
A disorder characterized by posterior microphthalmia, retinitis pigmentosa, foveoschisis and optic disk drusen. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.
Topology
Cytoplasmic: 1-69
Helical: 70-90
Extracellular: 91-579
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Anti-MFRP antibodies

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Mouse Anti-MFRP Recombinant Antibody (1E12) (CBMAB-A5445-LY)

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Target: MFRP
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: 1E12
Application*: WB, E
Datasheet SDS

Rat Anti-MFRP (AA 101-579) Recombinant Antibody (CBFYM-2160) (CBMAB-M2342-FY)

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Target: MFRP
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2160
Application*: P
Datasheet SDS

Mouse Anti-MFRP (AA 480-580) Recombinant Antibody (CBFYM-2159) (CBMAB-M2341-FY)

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Target: MFRP
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: CBFYM-2159
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-MFRP Recombinant Antibody (CBFYM-0631) (CBMAB-M0766-FY)

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Target: MFRP
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: CBFYM-0631
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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