MLLT1

MLLT1 (MLLT1, Super Elongation Complex Subunit) is a Protein Coding gene. Diseases associated with MLLT1 include Borderline Leprosy and Indeterminate Leprosy. Among its related pathways are Gene Expression and Formation of HIV elongation complex in the absence of HIV Tat. An important paralog of this gene is MLLT3.

MLLT1, Super Elongation Complex Subunit

Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948).

Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114).

Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114).

Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription.

Chromatin remodeling Source: GO_Central
Histone acetylation Source: GO_Central
Negative regulation of protein kinase activity Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Nucleus

A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.