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MLLT1

MLLT1 (MLLT1, Super Elongation Complex Subunit) is a Protein Coding gene. Diseases associated with MLLT1 include Borderline Leprosy and Indeterminate Leprosy. Among its related pathways are Gene Expression and Formation of HIV elongation complex in the absence of HIV Tat. An important paralog of this gene is MLLT3.
Full Name
MLLT1, Super Elongation Complex Subunit
Function
Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948).

Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114).

Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114).

Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription.
Biological Process
Chromatin remodeling Source: GO_Central
Histone acetylation Source: GO_Central
Negative regulation of protein kinase activity Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.
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Anti-MLLT1 antibodies

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Mouse Anti-MLLT1 Recombinant Antibody (3H2) (CBMAB-A5515-LY)

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Target: MLLT1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3H2
Application*: WB, E
Datasheet SDS

Rabbit Anti-MLLT1 Recombinant Antibody (CBFYM-2301) (CBMAB-M2486-FY)

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Target: MLLT1
Host: Rabbit
Specificity: Human
Clone: CBFYM-2301
Application*: WB, CI
Datasheet SDS

Mouse Anti-MLLT1 (AA 414-472 ) Recombinant Antibody (CBFYM-2300) (CBMAB-M2485-FY)

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Target: MLLT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2300
Application*: WB
Datasheet SDS

Mouse Anti-MLLT1 (AA 472-559) Recombinant Antibody (CBFYM-2299) (CBMAB-M2484-FY)

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Target: MLLT1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2299
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-MLLT1 Recombinant Antibody (CBFYE-1555) (CBMAB-E2203-FY)

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Target: MLLT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1555
Application*: IB
Datasheet SDS

Mouse Anti-MLLT1 Recombinant Antibody (CBFYE-1554) (CBMAB-E2202-FY)

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Target: MLLT1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYE-1554
Application*: E, IF, WB
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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