MMP8

This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Full Name
Matrix Metallopeptidase 8
Function
Can degrade fibrillar type I, II, and III collagens.
Biological Process
Collagen catabolic process Source: GO_Central
Endodermal cell differentiation Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Negative regulation of gene expression Source: ARUK-UCL
Negative regulation of interleukin-10 production Source: ARUK-UCL
Positive regulation of DNA binding Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of interleukin-6 production Source: ARUK-UCL
Positive regulation of JNK cascade Source: ARUK-UCL
Positive regulation of MAPK cascade Source: ARUK-UCL
Positive regulation of microglial cell activation Source: ARUK-UCL
Positive regulation of neuroinflammatory response Source: ARUK-UCL
Positive regulation of NIK/NF-kappaB signaling Source: ARUK-UCL
Positive regulation of nitric oxide biosynthetic process Source: ARUK-UCL
Positive regulation of reactive oxygen species biosynthetic process Source: ARUK-UCL
Positive regulation of tumor necrosis factor production Source: ARUK-UCL
Proteolysis Source: UniProtKB
Regulation of microglial cell activation Source: ARUK-UCL
Regulation of neuroinflammatory response Source: ARUK-UCL
Cellular Location
Extracellular region or secreted
extracellular matrix
Other locations
Cytoplasmic granule
Note: Stored in intracellular granules.
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Anti-MMP8 antibodies

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Mouse Anti-MMP8 Recombinant Antibody (CBCNC-664) (CBMAB-C3947-CN)

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Target: MMP8
Host: Mouse
Specificity: Rat
Clone: CBCNC-664
Application*: WB, ICC, P, IH-F, E
Datasheet SDS

Mouse Anti-MMP8 Recombinant Antibody (CBFYM-2416) (CBMAB-M2603-FY)

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Target: MMP8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYM-2416
Application*: E, WB
Datasheet SDS

Mouse Anti-MMP8 Recombinant Antibody (CBFYM-2414) (CBMAB-M2601-FY)

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Target: MMP8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBFYM-2414
Application*: IH, WB
Datasheet SDS

Mouse Anti-MMP8 Recombinant Antibody (CBFYM-2413) (CBMAB-M2600-FY)

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Target: MMP8
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYM-2413
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-MMP8 Recombinant Antibody (CBFYM-0693) (CBMAB-M0829-FY)

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Target: MMP8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0693
Application*: IH, WB
Datasheet SDS

Rabbit Anti-MMP8 Recombinant Antibody (CBFYM-0093) (CBMAB-M0104-FY)

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Target: MMP8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0093
Application*: F
Datasheet SDS

Mouse Anti-MMP8 Recombinant Antibody (CBFYM-0015) (CBMAB-M0019-FY)

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Target: MMP8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0015
Application*: F
Datasheet SDS

Human Recombinant MMP8 protein, His Tag-1 (V2LY-0526-LY5620)

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Target: MMP8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-467
Tag: His Tag
In Vivo Assay
Datasheet SDS

Human Recombinant MMP8 protein, His Tag (V2LY-0526-LY5619)

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Target: MMP8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-467
Tag: His Tag
Datasheet SDS

Mouse Recombinant MMP8 protein, His Tag (V2LY-0526-LY8679)

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Target: MMP8
Expressed Host: CHO Stable Cells
Sequence: Amino Acid: 1-465
Tag: His Tag
Datasheet SDS

Mouse Recombinant MMP8 protein (V2LY-0526-LY8678)

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Target: MMP8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 21-465
Datasheet SDS

Human Recombinant MMP8 protein (V2LY-0526-LY5618)

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Target: MMP8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 21-467
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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