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Mouse Anti-MMP8 Recombinant Antibody (CBFYM-2414) (CBMAB-M2601-FY)

This product is mouse antibody that recognizes MMP8. The antibody CBFYM-2414 can be used for immunoassay techniques such as: IHC, WB.
See all MMP8 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBFYM-2414
Antibody Isotype
IgG1, k
Application
IHC, WB

Basic Information

Immunogen
MMP-8 purified from human neutrophils
Specificity
Human, Mouse
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.0, 2% BSA
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Matrix Metallopeptidase 8
Introduction
This gene encodes a member of the matrix metalloproteinase family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human4317
Mouse17394
UniProt ID
HumanP22894
MouseO70138
Alternative Names
Matrix Metallopeptidase 8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); Matrix Metalloproteinase-8; PMNL Collagenase; PMNL-CL; MMP-8; CLG1
Function
Can degrade fibrillar type I, II, and III collagens.
Biological Process
Collagen catabolic process Source: GO_Central
Endodermal cell differentiation Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Negative regulation of gene expression Source: ARUK-UCL
Negative regulation of interleukin-10 production Source: ARUK-UCL
Positive regulation of DNA binding Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of interleukin-6 production Source: ARUK-UCL
Positive regulation of JNK cascade Source: ARUK-UCL
Positive regulation of MAPK cascade Source: ARUK-UCL
Positive regulation of microglial cell activation Source: ARUK-UCL
Positive regulation of neuroinflammatory response Source: ARUK-UCL
Positive regulation of NIK/NF-kappaB signaling Source: ARUK-UCL
Positive regulation of nitric oxide biosynthetic process Source: ARUK-UCL
Positive regulation of reactive oxygen species biosynthetic process Source: ARUK-UCL
Positive regulation of tumor necrosis factor production Source: ARUK-UCL
Proteolysis Source: UniProtKB
Regulation of microglial cell activation Source: ARUK-UCL
Regulation of neuroinflammatory response Source: ARUK-UCL
Cellular Location
Extracellular region or secreted
extracellular matrix
Other locations
Cytoplasmic granule
Note: Stored in intracellular granules.

Baidya, S. K., Banerjee, S., Guti, S., Jha, T., & Adhikari, N. (2024). Matrix metalloproteinase-8 (MMP-8) and its inhibitors: A minireview. European Journal of Medicinal Chemistry Reports, 100130.

Atanasova, T., Stankova, T., Bivolarska, A., & Vlaykova, T. (2023). Matrix Metalloproteinases in Oral Health—Special Attention on MMP-8. Biomedicines, 11(6), 1514.

Luchian, I., Goriuc, A., Sandu, D., & Covasa, M. (2022). The role of matrix metalloproteinases (MMP-8, MMP-9, MMP-13) in periodontal and peri-implant pathological processes. International Journal of Molecular Sciences, 23(3), 1806.

Umeizudike, K., Räisänen, I., Gupta, S., Nwhator, S., Grigoriadis, A., Sakellari, D., & Sorsa, T. (2022). Active matrix metalloproteinase‐8: A potential biomarker of oral systemic link. Clinical and Experimental Dental Research, 8(1), 359-365.

Goncharova, E. A., Kudryashova, T. V., Maroli, G., & Pullamsetti, S. S. (2021). Matrix Metalloproteinase-8 in Pulmonary Hypertension: The Sheep in the Wolf’s Skin?. American Journal of Respiratory and Critical Care Medicine, 204(12), 1361-1363.

Dieffenbach, P. B., Mallarino Haeger, C., Rehman, R., Corcoran, A. M., Coronata, A. M. F., Vellarikkal, S. K., ... & Fredenburgh, L. E. (2021). A novel protective role for matrix metalloproteinase-8 in the pulmonary vasculature. American Journal of Respiratory and Critical Care Medicine, 204(12), 1433-1451.

Forsblom, E., Tervahartiala, T., Ruotsalainen, E., Järvinen, A., & Sorsa, T. (2021). Matrix metalloproteinase MMP-8, TIMP-1 and MMP-8/TIMP-1 ratio in plasma in methicillin-sensitive Staphylococcus aureus bacteremia. Plos one, 16(5), e0252046.

Orozco-Páez, J., Rodríguez-Cavallo, E., Díaz-Caballero, A., & Méndez-Cuadro, D. (2021). Quantification of matrix metalloproteinases MMP-8 and MMP-9 in gingival overgrowth. The Saudi Dental Journal, 33(5), 260-267.

Wu, W., Peng, S., Shi, Y., Li, L., Song, Z., & Lin, S. (2021). NPY promotes macrophage migration by upregulating matrix metalloproteinase‐8 expression. Journal of Cellular Physiology, 236(3), 1903-1912.

Juurikka, K., S. Butler, G., Salo, T., Nyberg, P., & Åström, P. (2019). The role of MMP8 in cancer: a systematic review. International journal of molecular sciences, 20(18), 4506.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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