RRAGA

RRAGA (Ras Related GTP Binding A) is a Protein Coding gene. Diseases associated with RRAGA include Nut Allergy. Among its related pathways are Metabolism of proteins and Gene Expression. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and GTP binding. An important paralog of this gene is RRAGB.

Full Name

Ras Related GTP Binding A

Function

Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:25936802).
Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form (PubMed:20381137, PubMed:24095279, PubMed:25936802).
In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:25936802).
Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008).
May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death (PubMed:8995684).
(Microbial infection) May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process cell deathManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to amino acid stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cytolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of autophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Lysosome
Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state (PubMed:8995684, PubMed:9394008).
Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane (PubMed:8995684).

PTM

Ubiquitinated. 'Lys-68'-linked polyubiquitination of the GDP-bound inactive form of RRAGA by RNF152 is increased in response to amino acid starvation. Polyubiquitination promotes interaction with the GATOR1 complex. This does not affect RRAGA degradation.