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SIX5

The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2.
Full Name
SIX5
Function
Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity).
Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity).
Biological Process
Biological Process lens development in camera-type eyeIEA:Ensembl
Biological Process Leydig cell proliferationIEA:Ensembl
Biological Process negative regulation of DNA-templated transcriptionIEA:Ensembl
Biological Process negative regulation of skeletal muscle satellite cell proliferationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatid developmentIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Branchiootorenal syndrome 2 (BOR2):
A syndrome characterized by branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, structural defects of the outer, middle or inner ear, and renal malformations.

Anti-SIX5 antibodies

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Mouse Anti-SIX5 Monoclonal Antibody (2B11) (CBMAB-0108-LY)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2B11
Application*: IP, M

Mouse Anti-SIX5 Monoclonal Antibody (2H4) (CBMAB-0109-LY)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2H4
Application*: IP, M

Mouse Anti-SIX5 Antibody (2A6) (CBMAB-1565CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A6
Application*: WB, IF

Mouse Anti-SIX5 Antibody (4H7) (CBMAB-1566CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H7
Application*: WB, IF

Mouse Anti-SIX5 Antibody (2H1) (CBMAB-1567CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H1
Application*: WB, IF

Mouse Anti-SIX5 Antibody (4E7) (CBMAB-1568CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E7
Application*: WB, IF

Mouse Anti-SIX5 Antibody (3B4) (CBMAB-1569CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B4
Application*: WB, IF

Mouse Anti-SIX5 Antibody (3D9) (CBMAB-1570CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D9
Application*: WB, IF

Mouse Anti-SIX5 Antibody (3E11) (CBMAB-1571CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E11
Application*: WB, IF

Mouse Anti-SIX5 Antibody (10B12) (CBMAB-1572CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B12
Application*: WB, IF

Mouse Anti-SIX5 Antibody (1C11) (CBMAB-1573CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C11
Application*: WB, IF

Mouse Anti-SIX5 Antibody (3G10) (CBMAB-1574CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G10
Application*: WB, IF

Mouse Anti-SIX5 Antibody (7G4) (CBMAB-1575CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7G4
Application*: WB, IF

Mouse Anti-SIX5 Antibody (6E10) (CBMAB-1576CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6E10
Application*: WB, IF

Mouse Anti-SIX5 Antibody (10B3) (CBMAB-1577CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B3
Application*: WB, IF

Mouse Anti-SIX5 Antibody (10D2) (CBMAB-1578CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10D2
Application*: WB, IF

Mouse Anti-SIX5 Antibody (9G10) (CBMAB-1579CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9G10
Application*: WB, IF

Mouse Anti-SIX5 Antibody (6C1) (CBMAB-1580CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6C1
Application*: WB, IF

Mouse Anti-SIX5 Antibody (3A1) (CBMAB-1581CQ)

Datasheet SDS
Target: SIX5
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 3A1
Application*: WB, IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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