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SIX5

The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2.
Full Name
SIX5
Function
Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity).
Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity).
Biological Process
Biological Process lens development in camera-type eyeIEA:Ensembl
Biological Process Leydig cell proliferationIEA:Ensembl
Biological Process negative regulation of DNA-templated transcriptionIEA:Ensembl
Biological Process negative regulation of skeletal muscle satellite cell proliferationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatid developmentIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Branchiootorenal syndrome 2 (BOR2):
A syndrome characterized by branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, structural defects of the outer, middle or inner ear, and renal malformations.
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Anti-SIX5 antibodies

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Mouse Anti-SIX5 Antibody (6C1) (CBMAB-1580CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6C1
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (10B3) (CBMAB-1577CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B3
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (3E11) (CBMAB-1571CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E11
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (4E7) (CBMAB-1568CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E7
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (2H1) (CBMAB-1567CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H1
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (4H7) (CBMAB-1566CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H7
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Monoclonal Antibody (2H4) (CBMAB-0109-LY)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2H4
Application*: IP, M
Datasheet SDS

Mouse Anti-SIX5 Monoclonal Antibody (2B11) (CBMAB-0108-LY)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2B11
Application*: IP, M
Datasheet SDS

Mouse Anti-SIX5 Antibody (3A1) (CBMAB-1581CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 3A1
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (9G10) (CBMAB-1579CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9G10
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (10D2) (CBMAB-1578CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10D2
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (6E10) (CBMAB-1576CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6E10
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (7G4) (CBMAB-1575CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7G4
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (3G10) (CBMAB-1574CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G10
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (1C11) (CBMAB-1573CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C11
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (10B12) (CBMAB-1572CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B12
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (3D9) (CBMAB-1570CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D9
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (3B4) (CBMAB-1569CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B4
Application*: WB, IF
Datasheet SDS

Mouse Anti-SIX5 Antibody (2A6) (CBMAB-1565CQ)

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Target: SIX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A6
Application*: WB, IF
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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