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SOX2

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
Full Name
SRY-Box 2
Function
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity).
Binds to the proximal enhancer region of NANOG (By similarity).
Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408).
Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
May function as a switch in neuronal development (By similarity).
Biological Process
Adenohypophysis developmentIEA:Ensembl
Anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cell fate commitmentManual Assertion Based On ExperimentIBA:GO_Central
Chromatin organization1 PublicationNAS:UniProtKB
Endodermal cell fate specificationManual Assertion Based On ExperimentIDA:MGI
Eye developmentManual Assertion Based On ExperimentIEP:UniProtKB
Forebrain developmentManual Assertion Based On ExperimentIEP:UniProtKB
Glial cell fate commitment1 PublicationNAS:UniProtKB
Inner ear developmentManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell cycle G1/S phase transitionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of epithelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of neuron differentiationISS:UniProtKB
Negative regulation of transcription by RNA polymerase IIISS:UniProtKB
Neuronal stem cell population maintenanceISS:UniProtKB
Osteoblast differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Pituitary gland developmentManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of cell differentiationIEA:Ensembl
Positive regulation of cell-cell adhesionIEA:Ensembl
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:HGNC-UCL
Response to growth factorManual Assertion Based On ExperimentIDA:UniProtKB
Response to woundingManual Assertion Based On ExperimentIEP:UniProtKB
Somatic stem cell population maintenanceManual Assertion Based On ExperimentIDA:UniProtKB
Tissue regenerationIEA:Ensembl
Cellular Location
Nucleus speckle
Cytoplasm
Nucleus
Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity).
Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity).
Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity).
Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity).
Involvement in disease
Microphthalmia, syndromic, 3 (MCOPS3):
A disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
PTM
Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.

Anti-SOX2 antibodies

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Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXS-2516
Application*: F, IC, WB
Target: SOX2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: CBXS-2426
Application*: IC, WB
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-2325
Application*: IP, CI
Target: SOX2
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2028
Application*: WB, IP, IF, P, E
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBXS-1474
Application*: WB, P, W, IF, SE
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1473
Application*: WB, IP, P
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10F10C9
Application*: E, WB
Target: SOX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat, Mouse, Chicken
Clone: CBXS-5520
Application*: WB, E, IC
Target: SOX2
Host: Rabbit
Specificity: Human, Mouse
Clone: CBXS-5451
Application*: F, IF, IP, WB, CI
Target: SOX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4733
Application*: E, F, IF, P, WB
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: CBXS-4715
Application*: WB, P, C, F, IF
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-3759
Application*: P
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey, Cattle, Dog, Horse
Clone: CBXS-6017
Application*: WB
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle, Dog, Horse
Clone: CBXS-6014
Application*: WB, IF, F
Target: SOX2
Host: Rabbit
Specificity: Mouse
Clone: CBXS-6003
Application*: WB, P
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Pig
Clone: CBXS-5676
Application*: E, IF, IH, WB, IR
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Fish, Human, Mouse
Clone: CBXS-4260
Application*: CI, F, IC, IF, P, IP, WB
Target: SOX2
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-3558
Application*: F
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Cattle, Dog, Horse
Clone: CBXS-5418
Application*: CI
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 57CT23.3.4
Application*: E, F, IF, IH, WB
Target: SOX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5093
Application*: WB, IH, P
Target: SOX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXS-1725
Application*: IS
Target: SOX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXS-1724
Application*: IS
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP76
Application*: P, WB
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10F10
Application*: IF, IC, IH, WB
Target: SOX2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: Btjce
Application*: E, IF, IC, P, F, WB
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EPR3131
Application*: IC, IF, P, E, WB
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 9-9-3
Application*: F, IC, IF, C, WB
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 20G5
Application*: F, IC, IF, P, IP, WB
Target: SOX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: SOX2/1791
Application*: P
Target: SOX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B3
Application*: IP
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF405
Application*: ELISA, WB, IHC
Target: SOX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Porcine, Mouse, Rat
Clone: CB09A
Application*: ELISA, WB
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10F10
Application*: WB, IF, IHC
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: IHC665
Application*: P, E, IH
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Bovine, Dog, Horse
Clone: L1D6A2
Application*: WB, IF (IC), F
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: C70B1
Application*: WB, P
Target: SOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey, Bovine, Dog, Horse
Clone: L73B4
Application*: WB
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D9B8N
Application*: WB, IP, IF, IF (IC), F, CI, CI-seq
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Bovine, Dog, Horse
Clone: D6D9
Application*: CI
Target: Sox2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 2A10-F11-F12
Application*: WB, F, IC
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Application*: WB
Target: SOX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A2I7G
Application*: WB, IP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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