STX5

This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Full Name

Syntaxin 5

Function

Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.
(Microbial infection) Required for the efficient production of infectious virion during human cytomegalovirus infection. Mechanistically, participates in the formation of the cytoplasmic viral assembly compartment where tegument acquisition and envelopment occur.

Biological Process

Biological Process early endosome to Golgi transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Golgi disassemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of Golgi organizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retrograde transport, endosome to GolgiManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusion with Golgi apparatusIEA:Ensembl

Cellular Location

Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus membrane
Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae.

Topology

Cytoplasmic: 1-333
Helical: 334-354
Vesicular: 355