TERF2
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
Full Name
telomeric repeat binding factor 2
Research Area
Epigenetics and nuclear signaling,Cancer
Function
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:15608617, PubMed:16166375, PubMed:20655466, PubMed:28216226, PubMed:9326950, PubMed:9326951, PubMed:9476899).
In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (PubMed:16166375, PubMed:20655466).
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (PubMed:16166375).
Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (PubMed:16166375).
Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (PubMed:20655466).
Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:20655466, PubMed:28216226).
Preferentially binds to positive supercoiled DNA (PubMed:15608617, PubMed:20655466).
Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (PubMed:20655466).
Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity).
In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (PubMed:16166375, PubMed:20655466).
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (PubMed:16166375).
Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (PubMed:16166375).
Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (PubMed:20655466).
Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:20655466, PubMed:28216226).
Preferentially binds to positive supercoiled DNA (PubMed:15608617, PubMed:20655466).
Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (PubMed:20655466).
Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity).
Biological Process
Axonal transport of messenger ribonucleoprotein complex
Cellular senescence
In utero embryonic development
Negative regulation of beta-galactosidase activity
Negative regulation of cellular senescence
Negative regulation of exonuclease activity
Negative regulation of gene expression
Negative regulation of t-circle formation
Negative regulation of telomere capping
Negative regulation of telomere maintenance
Negative regulation of telomere maintenance via recombination
Negative regulation of telomere maintenance via semi-conservative replication
Negative regulation of telomere maintenance via telomerase
Negative regulation of telomere maintenance via telomere lengthening
Negative regulation of telomere single strand break repair
Negative regulation of telomeric D-loop disassembly
Positive regulation of gene expression
Positive regulation of nitric-oxide synthase activity
Positive regulation of telomere maintenance
Protection from non-homologous end joining at telomere
Protein localization to chromosome, telomeric region
Regulation of telomere maintenance
Regulation of telomere maintenance via telomerase
RNA-templated DNA biosynthetic process
Telomere capping
Telomere maintenance
Telomeric D-loop disassembly
Telomeric loop formation
Cellular senescence
In utero embryonic development
Negative regulation of beta-galactosidase activity
Negative regulation of cellular senescence
Negative regulation of exonuclease activity
Negative regulation of gene expression
Negative regulation of t-circle formation
Negative regulation of telomere capping
Negative regulation of telomere maintenance
Negative regulation of telomere maintenance via recombination
Negative regulation of telomere maintenance via semi-conservative replication
Negative regulation of telomere maintenance via telomerase
Negative regulation of telomere maintenance via telomere lengthening
Negative regulation of telomere single strand break repair
Negative regulation of telomeric D-loop disassembly
Positive regulation of gene expression
Positive regulation of nitric-oxide synthase activity
Positive regulation of telomere maintenance
Protection from non-homologous end joining at telomere
Protein localization to chromosome, telomeric region
Regulation of telomere maintenance
Regulation of telomere maintenance via telomerase
RNA-templated DNA biosynthetic process
Telomere capping
Telomere maintenance
Telomeric D-loop disassembly
Telomeric loop formation
Cellular Location
Nucleus PROSITE-ProRule annotation
Chromosome, telomere
Note: Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
Chromosome, telomere
Note: Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
PTM
Phosphorylated upon DNA damage, most probably by ATM. Phosphorylated TERF2 is not bound to telomeric DNA, and rapidly localizes to damage sites.
Methylated by PRMT1 at multiple arginines within the N-terminal Arg-rich region. Methylation may control association with telomeres.
Methylated by PRMT1 at multiple arginines within the N-terminal Arg-rich region. Methylation may control association with telomeres.
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Anti-TERF2 antibodies
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CompareTarget: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4366
Application*: IH
Target: TERF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D1Y5D
Application*: WB, IP
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 9F10/1
Application*: IH, IF, IP, FN, WB
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: CBYJT-2536
Application*: WB
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-2535
Application*: WB, CI, F, E, IH, IC, IF, IP, P, C, PL, MC
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYJT-2534
Application*: WB, IP, P, IC, F, IF
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-2533
Application*: E, F, IC, IF, IH, IP, WB
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJT-2532
Application*: WB, IH, IC, IF, IP, FN
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-2531
Application*: WB, IH
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2530
Application*: WB
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H6B4
Application*: E, WB, P, IF, IC, F
Target: TERF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2529
Application*: WB, IP, F
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA46
Application*: E
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G5
Application*: IP, M
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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