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TERF2

This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]
Full Name
TERF2
Function
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
Biological Process
Biological Process anterograde axonal transport of messenger ribonucleoprotein complexSource:Ensembl
Biological Process cell cycleSource:UniProtKB-KW
Biological Process cellular senescenceSource:BHF-UCL1 Publication
Biological Process in utero embryonic developmentSource:Ensembl
Biological Process negative regulation of beta-galactosidase activitySource:BHF-UCL1 Publication
Biological Process negative regulation of cellular senescenceSource:BHF-UCL1 Publication
Biological Process negative regulation of exonuclease activitySource:BHF-UCL1 Publication
Biological Process negative regulation of gene expressionSource:BHF-UCL1 Publication
Biological Process negative regulation of t-circle formationSource:BHF-UCL1 Publication
Biological Process negative regulation of telomere cappingSource:BHF-UCL1 Publication
Biological Process negative regulation of telomere maintenanceSource:UniProtKB1 Publication
Biological Process negative regulation of telomere maintenance via recombinationSource:BHF-UCL1 Publication
Biological Process negative regulation of telomere maintenance via semi-conservative replicationSource:BHF-UCL1 Publication
Biological Process negative regulation of telomere maintenance via telomeraseSource:BHF-UCL1 Publication
Biological Process negative regulation of telomere maintenance via telomere lengtheningSource:BHF-UCL1 Publication
Biological Process negative regulation of telomere single strand break repairSource:BHF-UCL1 Publication
Biological Process negative regulation of telomeric D-loop disassemblySource:BHF-UCL1 Publication
Biological Process positive regulation of gene expressionSource:BHF-UCL1 Publication
Biological Process positive regulation of nitric-oxide synthase activitySource:BHF-UCL1 Publication
Biological Process positive regulation of telomere maintenanceSource:ComplexPortal1 Publication
Biological Process protection from non-homologous end joining at telomereSource:BHF-UCL2 Publications
Biological Process protein localization to chromosome, telomeric regionSource:BHF-UCL1 Publication
Biological Process regulation of telomere maintenanceSource:CACAO1 Publication
Biological Process regulation of telomere maintenance via telomeraseSource:BHF-UCL1 Publication
Biological Process RNA-templated DNA biosynthetic processSource:GOC
Biological Process telomere cappingSource:ComplexPortal1 Publication
Biological Process telomere maintenanceSource:UniProtKB1 Publication
Biological Process telomeric D-loop disassemblySource:BHF-UCL1 Publication
Biological Process telomeric loop formationSource:BHF-UCL1 Publication
Cellular Location
Nucleus
Chromosome, telomere
Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
PTM
Phosphorylated upon DNA damage, most probably by ATM. Phosphorylated TERF2 is not bound to telomeric DNA, and rapidly localizes to damage sites.
Methylated by PRMT1 at multiple arginines within the N-terminal Arg-rich region. Methylation may control association with telomeres.

Anti-TERF2 antibodies

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Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA46
Application*: E
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G5
Application*: IP, M
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: CBYJT-2536
Application*: WB
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-2535
Application*: WB, CI, F, E, IH, IC, IF, IP, P, C, PL, MC
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYJT-2534
Application*: WB, IP, P, IC, F, IF
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-2533
Application*: E, F, IC, IF, IH, IP, WB
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJT-2532
Application*: WB, IH, IC, IF, IP, FN
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-2531
Application*: WB, IH
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2530
Application*: WB
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H6B4
Application*: E, WB, P, IF, IC, F
Target: TERF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2529
Application*: WB, IP, F
Target: TERF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D1Y5D
Application*: WB, IP
Target: TERF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 9F10/1
Application*: IH, IF, IP, FN, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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