Tnfrsf23

Tnfrsf23 is a member of the tumor necrosis factor superfamily of proteins. Tnfrsf23 has been shown to bind to the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), but to have no signaling capacity. Tnfrsf23 shows elevated expression in mice with diet-induced fatty liver disease. Tnfrsf23 and other family members are present in a gene cluster on chromosome 7.

Full Name

Tumor Necrosis Factor Receptor Superfamily, Member 23

Function

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis through ligand competition. Cannot induce the NF-kappa-B pathway.

Biological Process

Biological Process activation-induced cell death of T cells Source:GO_Central1 Publication
Biological Process extrinsic apoptotic signaling pathway in absence of ligand Source:GO_Central1 Publication
Biological Process motor neuron apoptotic process Source:GO_Central1 Publication
Biological Process necroptotic signaling pathway Source:GO_Central1 Publication
Biological Process negative regulation of apoptotic process Source:GO_Central1 Publication
Biological Process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source:MGI1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source:GO_Central1 Publication
Biological Process regulation of stress-activated MAPK cascade Source:GO_Central1 Publication

Cellular Location

Cell membrane