TRPC3

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Full Name

TRPC3 Gene(Protein Coding) Transient Receptor Potential Cation Channel Subfamily C Member 3

Function

Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:8646775, PubMed:9417057, PubMed:9930701, PubMed:20095964, PubMed:30139744, PubMed:29726814, PubMed:35051376).
May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors (PubMed:8646775).

Biological Process

Biological Process calcium ion transmembrane transport Source:UniProtKB1 Publication
Biological Process calcium ion transport Source:ProtInc1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process phototransduction Source:ProtInc1 Publication
Biological Process positive regulation of calcium ion transport into cytosol Source:UniProtKB1 Publication
Biological Process positive regulation of cardiac muscle hypertrophy in response to stress Source:BHF-UCL1 Publication
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process response to ATP Source:UniProtKB1 Publication
Biological Process response to calcium ion Source:UniProtKB1 Publication
Biological Process single fertilization Source:GO_Central1 Publication

Cellular Location

Cell membrane

Involvement in disease

Spinocerebellar ataxia 41 (SCA41):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord.

Topology

Cytoplasmic: 1-459
Helical: 460-477
Extracellular: 478-508
Helical: 509-527
Cytoplasmic: 528-540
Helical: 541-562
Extracellular: 563-606
Helical: 607-630
Cytoplasmic: 631-649
Helical: 650-673
Extracellular: 674-713
Helical: 714-739
Cytoplasmic: 740-921