U2AF1

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
Full Name
U2 small nuclear RNA auxiliary factor 1
Function
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.
Biological Process
Biological Process mRNA processing Source:ProtInc1 Publication
Biological Process mRNA splicing, via spliceosome Source:GO_Central1 Publication
Biological Process RNA splicing Source:ProtInc1 Publication
Cellular Location
Nucleus
Nucleus speckle
Involvement in disease
Myelodysplastic syndrome (MDS):
A heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS); chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. MDS is considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML).
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Anti-U2AF1 antibodies

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Mouse Anti-U2AF1 Recombinant Antibody (CF462) (CBMAB-FT068LY)

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Target: U2AF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF462
Application*: ELISA, WB, IHC, IP
Datasheet SDS

Rabbit Anti-U2AF1 Recombinant Antibody (D6S3Q) (CBMAB-CP2916-LY)

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Target: U2AF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Hamster, Zebrafish, Cattle
Clone: D6S3Q
Application*: WB
Datasheet SDS

Mouse Anti-U2AF1 Recombinant Antibody (CBFYU-006) (CBMAB-U0006-FY)

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Target: U2AF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-006
Application*: E, WB, IH, IP
Datasheet SDS

Mouse Anti-U2AF1 Recombinant Antibody (CBFYU-004) (CBMAB-U0004-FY)

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Target: U2AF1
Host: Mouse
Specificity: Human
Clone: CBFYU-004
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-U2AF1 Recombinant Antibody (CBFYU-003) (CBMAB-U0003-FY)

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Target: U2AF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Hamster, Zebrafish, Cattle
Clone: CBFYU-003
Application*: WB
Datasheet SDS

Mouse Anti-U2AF1 Recombinant Antibody (CBFYU-002) (CBMAB-U0002-FY)

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Target: U2AF1
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: CBFYU-002
Application*: E, IH, IP, WB
Datasheet SDS

Mouse Anti-U2AF1 Recombinant Antibody (CBFYU-001) (CBMAB-U0001-FY)

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Target: U2AF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYU-001
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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