ZNF410

Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.
Full Name
ZNF410
Function
Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416, PubMed:33301730).
Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416, PubMed:33301730).
May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286).
May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215).
However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33859416, PubMed:33301730).
Biological Process
Biological Process negative regulation of gene expression Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Nucleus
Chromosome
Note: Directly binds to the sequence motif 5'-CATCCCATAATA-3'.
PTM
Sumoylated (PubMed:12370286).
Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation (PubMed:12370286).
O-glycosylated (PubMed:30078215).
O-GlcNAcylation may occur in response to increasing glucose levels and affect transcription factor activity (PubMed:30078215).
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Anti-ZNF410 antibodies

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Mouse Anti-ZNF410 Recombinant Antibody (2B7) (CBMAB-0831-LY)

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Target: ZNF410
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2B7
Application*: IP, M, WB
Datasheet SDS

Mouse Anti-ZNF410 Recombinant Antibody (2B4) (CBMAB-0830-LY)

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Target: ZNF410
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B4
Application*: M, WB
Datasheet SDS

Mouse Anti-ZNF410 Recombinant Antibody (1H9) (CBMAB-0829-LY)

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Target: ZNF410
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1H9
Application*: M, WB
Datasheet SDS

Mouse Anti-ZNF410 Recombinant Antibody (1D7) (CBMAB-0828-LY)

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Target: ZNF410
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D7
Application*: IP, M, WB
Datasheet SDS

Mouse Anti-ZNF410 Recombinant Antibody (1C7) (CBMAB-0827-LY)

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Target: ZNF410
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C7
Application*: IP, M, WB
Datasheet SDS

Mouse Anti-ZNF410 Recombinant Antibody (1A12) (CBMAB-0826-LY)

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Target: ZNF410
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1A12
Application*: IP, M, WB
Datasheet SDS

Mouse Anti-ZNF410 Recombinant Antibody (2C9) (CBMAB-0792-LY)

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Target: ZNF410
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2C9
Application*: CI, IP, M, WB
Datasheet SDS

Mouse Anti-ZNF410 Recombinant Antibody (3343C2a) (CBMAB-Z0573-WJ)

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Target: ZNF410
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3343C2a
Application*: DB, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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