Mouse Anti-ZNF410 Recombinant Antibody (1A12) (CBMAB-0826-LY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416, PubMed:33301730).
May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286).
May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215).
However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33859416, PubMed:33301730).
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Chromosome
Note: Directly binds to the sequence motif 5'-CATCCCATAATA-3'.
Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation (PubMed:12370286).
O-glycosylated (PubMed:30078215).
O-GlcNAcylation may occur in response to increasing glucose levels and affect transcription factor activity (PubMed:30078215).
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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