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Mouse Anti-ZNF410 Recombinant Antibody (1A12) (CBMAB-0826-LY)

This product is mouse antibody recognizes ZNF410 of human. The antibody 1A12 immunoassay techniques such as: IP, MA, WB.
See all ZNF410 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A12
Antibody Isotype
IgG2b
Application
IP, MA, WB

Basic Information

Immunogen
Recombinant peptide (aa 129-478)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ZNF410
Introduction
Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.
Entrez Gene ID
57862
UniProt ID
Q86VK4
Alternative Names
APA-1; APA1
Function
Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416, PubMed:33301730).
Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416, PubMed:33301730).
May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286).
May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215).
However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33859416, PubMed:33301730).
Biological Process
Biological Process negative regulation of gene expression Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Nucleus
Chromosome
Note: Directly binds to the sequence motif 5'-CATCCCATAATA-3'.
PTM
Sumoylated (PubMed:12370286).
Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation (PubMed:12370286).
O-glycosylated (PubMed:30078215).
O-GlcNAcylation may occur in response to increasing glucose levels and affect transcription factor activity (PubMed:30078215).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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