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Mouse Anti-ABCA4 Recombinant Antibody (3F4) (CBMAB-0977-CN)

This product is a mouse antibody that recognizes ABCA4 of bovine. The antibody 3F4 can be used for immunoassay techniques such as: WB, IHC.
Host Animal
Mouse
Application
WB, IHC
Immunogen
Partially purified bovine 220-kDa disc rim protein
Antibody Isotype
IgG
Specificity
Bovine
Cross Reactivity
Human, Mouse, Bovine, Xenopus
Clone
3F4
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. The protein may play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
Alternative Name
retinal-specific ATP-binding cassette transporter; ATP-binding cassette, sub-family A (ABC1), member 4
Entrez Gene ID
UniProt ID
Cat CBMAB-0977-CN
Conjugates
Size
Price $
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