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Mouse Anti-ACE1 Recombinant Antibody (V2-179271) (CBMAB-A0544-YC)

Provided herein is a Mouse monoclonal antibody against Mouse angiotensin I converting enzyme. The antibody can be used for immunoassay techniques, such as WB.
See all ACE1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
V2-179271
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Purified recombinant human Angiotensin Converting Enzyme 1 protein fragments expressed in E.coli.
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% Glycerol, 0.5% BSA
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Angiotensin I Converting Enzyme
Introduction
ACE1 has biased expression in lung adult (RPKM 304.6), duodenum adult (RPKM 225.6) and 6 other tissues.
Entrez Gene ID
11421
UniProt ID
P09470
Alternative Names
CD143; AW208573; angiotensin-converting enzyme; dipeptidyl carboxypeptidase I; dipeptidyl peptidase; kininase II; EC 3.4.15.1
Function
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Biological Process
Amyloid-beta metabolic process
Angiotensin maturation
Antigen processing and presentation of peptide antigen via MHC class I
Arachidonic acid secretion
Blood vessel diameter maintenance
Blood vessel remodeling
Cell proliferation in bone marrow
Heart contraction
Hematopoietic stem cell differentiation
Hormone catabolic process
Kidney development
Mononuclear cell proliferation
Negative regulation of gap junction assembly
Negative regulation of gene expression
Negative regulation of protein binding
Neutrophil mediated immunity
Peptide catabolic process
Positive regulation of peptidyl-cysteine S-nitrosylation
Positive regulation of peptidyl-tyrosine autophosphorylation
Positive regulation of protein binding
Positive regulation of protein tyrosine kinase activity
Positive regulation of systemic arterial blood pressure
Posttranscriptional regulation of gene expression
Proteolysis
Regulation of angiotensin metabolic process
Regulation of blood pressure
Regulation of hematopoietic stem cell proliferation
Regulation of renal output by angiotensin
Regulation of smooth muscle cell migration
Regulation of systemic arterial blood pressure by renin-angiotensin
Regulation of vasoconstriction
Spermatogenesis
Cellular Location
Secreted; Cell membrane; Cytoplasm. Detected in both cell membrane and cytoplasm in neurons.
Involvement in disease
A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke.
Topology
Extracellular: 30-1256 aa
Helical: 1257-1277 aa
Cytoplasmic: 1278-1306 aa
PTM
Phosphorylated by CK2 on Ser-1299; which allows membrane retention.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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