Mouse Anti-AGT Recombinant Antibody (CBT4379) (V2LY-0625-LY2308)

Angiotensinogen

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Angiotensin-2: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
Angiotensin-3: Stimulates aldosterone release.
Angiotensin 1-7: Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Activation of MAPK activity
Angiotensin-activated signaling pathway
Blood vessel remodeling
Cell-cell signaling
G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
Kidney development
Low-density lipoprotein particle remodeling
Maintenance of blood vessel diameter homeostasis by renin-angiotensin
Negative regulation of endopeptidase activity
Negative regulation of gene expression
Negative regulation of MAP kinase activity
Negative regulation of neurotrophin TRK receptor signaling pathway
Negative regulation of sodium ion transmembrane transporter activity
Nitric oxide mediated signal transduction
Phospholipase C-activating G protein-coupled receptor signaling pathway
Positive regulation of activation of Janus kinase activity
Positive regulation of branching involved in ureteric bud morphogenesis
Positive regulation of cardiac muscle hypertrophy
Positive regulation of cellular protein metabolic process
Positive regulation of cholesterol esterification
Positive regulation of cytokine production
Positive regulation of endothelial cell migration
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of extrinsic apoptotic signaling pathway
Positive regulation of fibroblast proliferation
Positive regulation of gap junction assembly
Positive regulation of inflammatory response
Positive regulation of macrophage derived foam cell differentiation
Positive regulation of membrane hyperpolarization
Positive regulation of NAD(P)H oxidase activity
Positive regulation of NF-kappaB transcription factor activity
Positive regulation of peptidyl-tyrosine phosphorylation
Positive regulation of phosphatidylinositol 3-kinase signaling
Positive regulation of protein tyrosine kinase activityPositive regulation of reactive oxygen species metabolic process
Positive regulation of transcription, DNA-templated
Regulation of blood pressure
Regulation of blood volume by renin-angiotensin
Regulation of cardiac conduction
Regulation of cell growth
Regulation of cell population proliferation
Regulation of extracellular matrix assembly
Regulation of metabolic process
Regulation of renal output by angiotensin
Regulation of renal sodium excretion
Regulation of vasoconstriction
Renal system process
Renin-angiotensin regulation of aldosterone production
Response to muscle activity involved in regulation of muscle adaptation
Vasoconstriction

Secreted

Essential hypertension (EHT): A condition in which blood pressure is consistently higher than normal with no identifiable cause.
Renal tubular dysgenesis (RTD): Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).

Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).
The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.