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Rabbit Anti-APP Recombinant Antibody (BA0277) (CBMAB-0081CQ)

This product is a rabbit antibody that recognizes APP. The antibody BA0277 can be used for immunoassay techniques such as: WB.
Host Species
Rabbit
Application
WB
Immunogen
Human Amyloid Precursor Protein aa 50-150 (N terminal)
Antibody Isotype
IgG
Specificity
Human, Mouse, Rat
Clone
BA0277
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. APP gene contains 19 exons and spans more than 170 kb. APP has several isoforms generated by alternative splicing of exons 1-13, 13a, and 14-18. The predominant transcripts are APP695 (exons 1-6, 9-18, not 13a), APP751 (exons 1-7, 9-18, not 13a), and APP770 (exons 1-18, not 13a). Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Alternative Name
Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid Peptide; Peptidase Nexin-II; Protease Nexin-II; PN-II; PreA4; ABPP; APPI; CVAP; AD1; Beta-Amyloid Peptide(1-40); Beta-Amyloid Peptide(1-42); Beta-Amyloid Peptide; Alzheimer Disease; CTFgamma; ABETA; AAA; PN2; A4
Entrez Gene ID
Human351
Mouse11820
Rat54226
UniProt ID
HumanP05067
MouseP12023
RatP08592
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-0081CQ
Conjugates
Size
Price $
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Second antibody and isotype control