Mouse Anti-ATL1 Recombinant Antibody (CBT4173) (V2LY-0625-LY703)

Name: Mouse Anti-ATL1 Recombinant Antibody (CBT4173)
SKU: V2LY-0625-LY703
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-ATL1 Recombinant Antibody (CBT4173) (V2LY-0625-LY703) in ELISA

Mouse Anti-ATL1 Recombinant Antibody (CBT4173) (V2LY-0625-LY703) in WB

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4173

Application

Immunogen

Purified recombinant fragment of human ATL1 (AA: 1-100) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Atlastin GTPase 1

Entrez Gene ID

51062

UniProt ID

Q8WXF7

Function

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:27619977).
May also regulate Golgi biogenesis. May regulate axonal development.

Biological Process

Axonogenesis Source: UniProtKB
Endoplasmic reticulum organization Source: UniProtKB
Endoplasmic reticulum tubular network membrane organization Source: UniProtKB
Protein homooligomerization Source: UniProtKB

Cellular Location

Golgi apparatus membrane; Endoplasmic reticulum membrane; Axon. Localizes to endoplasmic reticulum tubular network (PubMed:27619977).

Involvement in disease

Spastic paraplegia 3, autosomal dominant (SPG3): A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Neuropathy, hereditary sensory, 1D (HSN1D): A disease characterized by adult-onset distal axonal sensory neuropathy leading to mutilating ulcerations as well as hyporeflexia. Some patients may show features suggesting upper neuron involvement.

Topology

Cytoplasmic: 1-449 aa
Helical: 450-470 aa
Lumenal: 471 aa
Helical: 472-492 aa
Cytoplasmic: 493-558 aa

Liu, X., Guo, X., Niu, L., Li, X., Sun, F., Hu, J., ... & Shen, K. (2019). Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites. Nature communications, 10(1), 1-15.

Shen, W., Liu, B., Liu, Z., Feng, J., Liu, C., & Kong, X. (2017). Host protein atlastin-1 promotes human immunodeficiency virus (HIV-1) replication. Virologica Sinica, 32(4), 338-341.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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