Mouse Anti-B3GALNT2 Recombinant Antibody (CBYY-0068) (CBMAB-0068-YY)

Name: Mouse Anti-B3GALNT2 Recombinant Antibody (CBYY-0068)
SKU: CBMAB-0068-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYY-0068

Application

Immunogen

Full length human recombinant protein of human B3GALNT2 produced in HEK293T cell.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Beta-1,3-N-Acetylgalactosaminyltransferase 2

Introduction

This gene encodes a member of the glycosyltransferase 31 family. The encoded protein synthesizes GalNAc:beta-1,3GlcNAc, a novel carBovinehydrate structure, on N- and O-glycans. Alternatively spliced transcript variants that encode different isoforMouse have been described. [provided by RefSeq, Mar 2013]

Entrez Gene ID

148789

UniProt ID

Q8NCR0

Alternative Names

Beta-1,3-N-Acetylgalactosaminyltransferase 2; UDP-GalNAc:BetaGlcNAc Beta-1,3-Galactosaminyltransferase, Polypeptide 2; Beta-1,3-GalNAc-T2; UDP-GalNAc:Beta-1,3-N-Acetylgalactosaminyltransferase 2; Beta-1,3-N-Acetylgalactosaminyltransferase II; EC 2.4.1.313; B3GalNAc-T2; EC 2.4.1; MDDGA11;

Function

Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.

Biological Process

Protein glycosylation Source: UniProtKB
Protein O-linked glycosylation Source: UniProtKB

Cellular Location

Endoplasmic reticulum; Golgi apparatus membrane

Involvement in disease

Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A11 (MDDGA11): An autosomal recessive disorder characterized by congenital muscular dystrophy associated with cobblestone lissencephaly and other brain anomalies, eye malformations, profound mental retardation, and death usually in the first years of life. Included diseases are the more severe Walker-Warburg syndrome and the slightly less severe muscle-eye-brain disease.

Topology

Cytoplasmic: 1-6 aa
Helical: 7-23 aa
Lumenal: 24-500 aa

PTM

N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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