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Mouse Anti-B3GALNT2 Recombinant Antibody (CBYY-0068) (CBMAB-0068-YY)

This product is mouse antibody that recognizes B3GALNT2. The antibody CBYY-0068 can be used for immunoassay techniques such as: WB
See all B3GALNT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-0068
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human B3GALNT2 produced in HEK293T cell.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Beta-1,3-N-Acetylgalactosaminyltransferase 2
Introduction
This gene encodes a member of the glycosyltransferase 31 family. The encoded protein synthesizes GalNAc:beta-1,3GlcNAc, a novel carBovinehydrate structure, on N- and O-glycans. Alternatively spliced transcript variants that encode different isoforMouse have been described. [provided by RefSeq, Mar 2013]
Entrez Gene ID
148789
UniProt ID
Q8NCR0
Alternative Names
Beta-1,3-N-Acetylgalactosaminyltransferase 2; UDP-GalNAc:BetaGlcNAc Beta-1,3-Galactosaminyltransferase, Polypeptide 2; Beta-1,3-GalNAc-T2; UDP-GalNAc:Beta-1,3-N-Acetylgalactosaminyltransferase 2; Beta-1,3-N-Acetylgalactosaminyltransferase II; EC 2.4.1.313; B3GalNAc-T2; EC 2.4.1; MDDGA11;
Function
Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.
Biological Process
Protein glycosylation Source: UniProtKB
Protein O-linked glycosylation Source: UniProtKB
Cellular Location
Endoplasmic reticulum; Golgi apparatus membrane
Involvement in disease
Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A11 (MDDGA11): An autosomal recessive disorder characterized by congenital muscular dystrophy associated with cobblestone lissencephaly and other brain anomalies, eye malformations, profound mental retardation, and death usually in the first years of life. Included diseases are the more severe Walker-Warburg syndrome and the slightly less severe muscle-eye-brain disease.
Topology
Cytoplasmic: 1-6 aa
Helical: 7-23 aa
Lumenal: 24-500 aa
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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