Mouse Anti-BRCA1 Recombinant Antibody (47) (CBMAB-AP673LY)







Basic Information
Application | Note |
WB | 1:100-1:1,000 |
IP | 1-2 µg per 100-500 µg of total protein (1 ml of cell lysate) |
IF(ICC) | 1:50-1:500 |
ELISA | 1:100-1:1,000 |
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688).
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172).
Regulates centrosomal microtubule nucleation (PubMed:18056443).
Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:12183412, PubMed:11836499, PubMed:19261748).
Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909).
Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698).
Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211).
Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604).
Acts as a transcriptional activator (PubMed:20160719).
Cellular response to indole-3-methanol Source: UniProtKB
Cellular response to tumor necrosis factor Source: BHF-UCL
Centrosome cycle Source: Ensembl
Chordate embryonic development Source: GO_Central
Chromosome segregation Source: UniProtKB
DNA double-strand break processing Source: Reactome
DNA replication Source: Reactome
Dosage compensation by inactivation of X chromosome Source: GO_Central
Double-strand break repair Source: CACAO
Double-strand break repair via homologous recombination Source: HGNC-UCL
Double-strand break repair via nonhomologous end joining Source: Reactome
Fatty acid biosynthetic process Source: UniProtKB-KW
Intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
Mitotic G2/M transition checkpoint Source: Ensembl
Negative regulation of centriole replication Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
Negative regulation of fatty acid biosynthetic process Source: UniProtKB
Negative regulation of G0 to G1 transition Source: Reactome
Negative regulation of histone acetylation Source: GO_Central
Negative regulation of histone H3-K4 methylation Source: Ensembl
Negative regulation of histone H3-K9 methylation Source: BHF-UCL
Negative regulation of intracellular estrogen receptor signaling pathway Source: CACAO
Negative regulation of reactive oxygen species metabolic process Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell cycle arrest Source: BHF-UCL
Positive regulation of DNA repair Source: UniProtKB
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of histone acetylation Source: BHF-UCL
Positive regulation of histone H3-K4 methylation Source: BHF-UCL
Positive regulation of histone H3-K9 acetylation Source: BHF-UCL
Positive regulation of histone H3-K9 methylation Source: Ensembl
Positive regulation of histone H4-K16 acetylation Source: BHF-UCL
Positive regulation of histone H4-K20 methylation Source: BHF-UCL
Positive regulation of protein ubiquitination Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of vascular endothelial growth factor production Source: BHF-UCL
Postreplication repair Source: HGNC-UCL
Protein autoubiquitination Source: UniProtKB
Protein deubiquitination Source: Reactome
Protein K6-linked ubiquitination Source: UniProtKB
Protein ubiquitination Source: HGNC-UCL
Regulation of DNA methylation Source: Ensembl
Regulation of gene expression by genetic imprinting Source: Ensembl
Regulation of signal transduction by p53 class mediator Source: Reactome
Regulation of transcription by RNA polymerase II Source: UniProtKB
Response to estrogen Source: UniProtKB
Response to ionizing radiation Source: UniProtKB
Signal transduction involved in G2 DNA damage checkpoint Source: UniProtKB
Isoform 3: Cytoplasm
Isoform 5: Cytoplasm
Breast-ovarian cancer, familial, 1 (BROVCA1): Disease susceptibility is associated with variants affecting the gene represented in this entry. Mutations in BRCA1 are thought to be responsible for more than 80% of inherited breast-ovarian cancer. A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate.
Ovarian cancer (OC): The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
Pancreatic cancer 4 (PNCA4): A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.
Fanconi anemia, complementation group S (FANCS): A form of Fanconi anemia, a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Autoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote degradation.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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