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Mouse Anti-CBR3 Recombinant Antibody (CBFYC-0892) (CBMAB-C0947-FY)


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Published Data
CBMAB-C0947-FY-1
Mouse Anti-CBR3 Recombinant Antibody (CBFYC-0892) (CBMAB-C0947-FY) in IP
PSMB4-WT-HA or PSMB-des-HA and CBR3 were overexpressed in HEK293T cell. Lysates were subjected to IP using either anti-HA agarose as a control. ...View More
Deshmukh, F. K., Ben-Nissan, G., Olshina, M. A., Füzesi-Levi, M. G., Polkinghorn, C., Arkind, G., ... & Sharon, M. (2023). Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family. Nature communications, 14(1), 3126.
CBMAB-C0947-FY-2
Mouse Anti-CBR3 Recombinant Antibody (CBFYC-0892) (CBMAB-C0947-FY) in WB
Escherichia coli cell lysates overexpressing FLAG-tagged human β-subunits PSMB1 to PSMB7 were incubated with His6-CBR3 bound to Ni-beads for pull-down experiments. Bound subunits were detected using an anti-FLAG antibody. ...View More
Deshmukh, F. K., Ben-Nissan, G., Olshina, M. A., Füzesi-Levi, M. G., Polkinghorn, C., Arkind, G., ... & Sharon, M. (2023). Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family. Nature communications, 14(1), 3126.

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-0892
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 126-176 mapping within an internal region of Carbonyl reductase 3 of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Carbonyl Reductase 3
Introduction
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene-CBR1.
Entrez Gene ID
Human874
Mouse109857
Rat304078
Dog487748
UniProt ID
HumanO75828
MouseQ8K354
RatB2GV72
DogL7N0B9
Alternative Names
Carbonyl Reductase 3; Short Chain Dehydrogenase/Reductase Family 21C Member 2; NADPH-Dependent Carbonyl Reductase 3; EC 1.1.1.184; Short Chain Dehydrogenase/Reductase Family 21C, Member 2; Epididymis Secretory Protein Li 25; Carbonyl Reductase (NADPH) 3
Function
Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).
Biological Process
Cognition Source: UniProtKB
Phylloquinone catabolic process Source: Ensembl
Xenobiotic metabolic process Source: Reactome
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

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