Mouse Anti-CNTFR Recombinant Antibody (CBFYC-2013) (V2LY-1206-LY525)

Name: Mouse Anti-CNTFR Recombinant Antibody (CBFYC-2013)
SKU: V2LY-1206-LY525
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-2013

Application

WB, IP, IF, ELISA, FC, IHC-P

Immunogen

Full length CNTFR α transfected Sf21 cells of human.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Dog

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

<0.1% sodium azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Ciliary Neurotrophic Factor Receptor

Entrez Gene ID

Human	1271
Mouse	12804
Rat	313173

UniProt ID

Human	P26992
Mouse	O88507
Rat	Q08406

Function

Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303).

Biological Process

Brainstem development Source: Ensembl
Ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Negative regulation of neuron apoptotic process Source: Ensembl
Nervous system development Source: ProtInc
Positive regulation of cell population proliferation Source: Ensembl
Sex differentiation Source: Ensembl
Signal transduction Source: ProtInc
Skeletal muscle organ development Source: Ensembl
Suckling behavior Source: Ensembl

Cellular Location

Cell membrane

Zhong, P., Zeng, G., Lei, C., Tian, G., Ouyang, S., Liu, F., & Peng, J. (2021). Ciliary neurotrophic factor overexpression protects the heart against pathological remodelling in angiotensin II-infused mice. Biochemical and Biophysical Research Communications, 547, 15-22.

Homma, H., Kobatake, N., Sekimoto, Y., Saito, M., Mochizuki, Y., Okamoto, T., ... & Kikuchi, N. (2020). Ciliary neurotrophic factor receptor rs41274853 polymorphism is associated with weightlifting performance in Japanese weightlifters. The Journal of Strength & Conditioning Research, 34(11), 3037-3041.

Jia, C., Oliver, J., Gilmer, D., Lovins, C., Rodriguez-Gil, D. J., & Hagg, T. (2020). Inhibition of focal adhesion kinase increases adult olfactory stem cell self-renewal and neuroregeneration through ciliary neurotrophic factor. Stem cell research, 49, 102061.

Wang, L., Zhang, H., & Lei, D. (2019). microRNA-146a promotes growth of acute leukemia cells by downregulating ciliary neurotrophic factor receptor and activating JAK2/STAT3 signaling. Yonsei Medical Journal, 60(10), 924-934.

Jia, C., Brown, R. W., Malone, H. M., Burgess, K. C., Gill, W. D., Keasey, M. P., & Hagg, T. (2019). Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice. Psychoneuroendocrinology, 100, 96-105.

Zheng, K., Zhang, Q., Sheng, Z., Li, Y., & Lu, H. H. (2018). Ciliary neurotrophic factor (CNTF) protects myocardial cells from oxygen glucose deprivation (OGD)/re-oxygenation via activation of Akt-Nrf2 signaling. Cellular Physiology and Biochemistry, 51(4), 1852-1862.

Ghasemi, M., Alizadeh, E., Saei Arezoumand, K., Fallahi Motlagh, B., & Zarghami, N. (2018). Ciliary neurotrophic factor (CNTF) delivery to retina: an overview of current research advancements. Artificial cells, nanomedicine, and biotechnology, 46(8), 1694-1707.

Baek, J. Y., Jeong, J. Y., Kim, K. I., Won, S. Y., Chung, Y. C., Nam, J. H., ... & Jin, B. K. (2018). Inhibition of microglia-derived oxidative stress by ciliary neurotrophic factor protects dopamine neurons in vivo from MPP+ neurotoxicity. International journal of molecular sciences, 19(11), 3543.

Li, S., Sato, K., Gordon, W. C., Sendtner, M., Bazan, N. G., & Jin, M. (2018). Ciliary neurotrophic factor (CNTF) protects retinal cone and rod photoreceptors by suppressing excessive formation of the visual pigments. Journal of Biological Chemistry, 293(39), 15256-15268.

Shpak, A. A., Guekht, A. B., Druzhkova, T. A., Kozlova, K. I., & Gulyaeva, N. V. (2017). Ciliary neurotrophic factor in patients with primary open-angle glaucoma and age-related cataract. Molecular vision, 23, 799.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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