Mouse Anti-CREB1 Recombinant Antibody (CBYY-C0532) (CBMAB-C1590-YY)

CAMP Responsive Element Binding Protein 1

C-C Motif Chemokine Receptor 3; Chemokine (C-C Motif) Receptor 3; Eosinophil Eotaxin Receptor; C-C CKR-3; CC-CKR-3; CMKBR3; CCR-3; CKR3;

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Aging Source: Ensembl
Axonogenesis Source: Ensembl
Cellular response to fatty acid Source: Ensembl
Cellular response to hepatocyte growth factor stimulus Source: Ensembl
Cellular response to insulin-like growth factor stimulus Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Cellular response to nerve growth factor stimulus Source: Ensembl
Cellular response to platelet-derived growth factor stimulus Source: Ensembl
Cellular response to retinoic acid Source: ARUK-UCL
Cellular response to zinc ion Source: Ensembl
Chemotaxis to arachidonic acid Source: Ensembl
Circadian rhythm Source: UniProtKB
Lactation Source: Ensembl
Lung saccule development Source: Ensembl
Memory Source: Ensembl
Negative regulation of gene expression Source: Ensembl
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of neuron death Source: Ensembl
Negative regulation of transcription by competitive promoter binding Source: BHF-UCL
Pituitary gland development Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of cardiac muscle tissue development Source: Ensembl
Positive regulation of fat cell differentiation Source: UniProtKB
Positive regulation of hormone secretion Source: Ensembl
Positive regulation of lipid biosynthetic process Source: UniProtKB
Positive regulation of long-term synaptic potentiation Source: Ensembl
Positive regulation of multicellular organism growth Source: Ensembl
Positive regulation of osteoclast differentiation Source: Ensembl
Positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of transforming growth factor beta3 production Source: Ensembl
Protein phosphorylation Source: MGI
Protein stabilization Source: UniProtKB
Regulation of cell size Source: Ensembl
Regulation of circadian rhythm Source: Ensembl
Regulation of fibroblast proliferation Source: Ensembl
Regulation of glial cell proliferation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to activity Source: Ensembl
Response to drug Source: Ensembl
Response to glucagon Source: UniProtKB
Response to hypoxia Source: Ensembl
Response to L-glutamate Source: Ensembl
Response to nicotine Source: Ensembl
Response to organic substance Source: MGI
Secretory granule organization Source: Ensembl
Signal transduction Source: ProtInc
Transcription by RNA polymerase II Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: Ensembl
Type I pneumocyte differentiation Source: Ensembl
Viral process Source: UniProtKB-KW
Visual learning Source: Ensembl

Nucleus

Angiomatoid fibrous histiocytoma (AFH):
The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.

timulated by phosphorylation. Phosphorylation of both Ser-119 and Ser-128 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-119 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-119 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-119. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-128. Phosphorylation of Ser-128 blocks CREB-mediated transcription even when Ser-119 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-257 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-119 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Phosphorylated by TSSK4 on Ser-119 (PubMed:15964553).
Sumoylated with SUMO1. Sumoylation on Lys-290, but not on Lys-271, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.