Mouse Anti-CTNND2 Recombinant Antibody (CBYCD-134) (V2LY-0125-LY353)

Name: Mouse Anti-CTNND2 Recombinant Antibody (CBYCD-134)
SKU: V2LY-0125-LY353
Rating: 5 (1 reviews)

See all CTNND2 antibodies

Compare Online Inquiry

Published Data

Mouse Anti-CTNND2 Recombinant Antibody (CBYCD-134) (V2LY-0125-LY353) in IHC

Immunohistochemistry reveals weak to strong delta-catenin expression in medulloblastoma tissues. ...View More

Hu, Y., Zhu, S., Xu, R., Wang, M., Chen, F., Zhang, Z., ... & Wang, J. (2022). Delta-catenin attenuates medulloblastoma cell invasion by targeting EMT pathway. Frontiers in Genetics, 13, 867872. Distributed under Open Access license CC BY 4.0, without modification.

Mouse Anti-CTNND2 Recombinant Antibody (CBYCD-134) (V2LY-0125-LY353) in ELISA

The number of IBA1+cells expressing the cellular protrusion/neuritogenic genes were quantified in the cortical plate region. n=(4-5/2) male mice/ litters per molecule for Saline and MIA, n=3 for scramble control probe. *p<0.05, **p<0.01, ns denotes no significance, by unpaired Student t test. Graphs indicate mean±s.e.m. ELISA verification of selected RNA-seq molecules. ...View More

Ikezu, S., Yeh, H., Delpech, J. C., Woodbury, M. E., Van Enoo, A. A., Ruan, Z., ... & Ikezu, T. (2021). Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Molecular psychiatry, 26(6), 1808-1831. Distributed under Open Access license CC BY 4.0, without modification.

Mouse Anti-CTNND2 Recombinant Antibody (CBYCD-134) (V2LY-0125-LY353) in WB

Western blot of cerebral cortex and cerebella, dissected without nearby ventricles, of WT and αT-cat KO mice. ...View More

Folmsbee, S. S., Wilcox, D. R., Tyberghein, K., De Bleser, P., Tourtellotte, W. G., van Hengel, J., ... & Gottardi, C. J. (2016). αT-catenin in restricted brain cell types and its potential connection to autism. Journal of molecular psychiatry, 4, 1-13. Distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCD-134

Application

WB, IP, IF, ELISA, IHC-P

Immunogen

Recombinant protein mapping within amino acids 1081-1191 of human δ-catenin.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.1 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)

Entrez Gene ID

Human	1501
Mouse	18163
Rat	114028

UniProt ID

Human	Q9UQB3
Mouse	O35927
Rat	O35116

Function

Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484).

Involved in the regulation of Wnt signaling (PubMed:25807484).

It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity).

Functions as a transcriptional activator when bound to ZBTB33 (By similarity).

May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.

Biological Process

Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Dendritic spine morphogenesis Source: UniProtKB
Regulation of canonical Wnt signaling pathway Source: UniProtKB
Signal transduction Source: ProtInc
Synapse organization Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Nucleus; Adherens junction; Dendrite; Perikaryon

Involvement in disease

Defects in CTNND2, including deleterious missense and copy number variants (CNVs) are involved in autism, a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.

PTM

O-glycosylated.
Phosphorylated by CDK5 (By similarity). Phosphorylated by GSK3B (PubMed:19706605).

Adegbola, A., Lutz, R., Nikkola, E., Strom, S. P., Picker, J., & Wynshaw-Boris, A. (2020). Disruption of CTNND2, encoding delta-catenin, causes a penetrant attention deficit disorder and myopia. Human Genetics and Genomics Advances, 1(1), 100007.

Stern, E. P., Guerra, S. G., Chinque, H., Acquaah, V., González-Serna, D., Ponticos, M., ... & Denton, C. P. (2020). Analysis of anti-RNA polymerase III antibody-positive systemic sclerosis and altered GPATCH2L and CTNND2 expression in scleroderma renal crisis. The Journal of Rheumatology, 47(11), 1668-1677.

Arpón, A., Santos, J. L., Milagro, F. I., Cataldo, L. R., Bravo, C., Riezu-Boj, J. I., & Martínez, J. A. (2019). Insulin sensitivity is associated with lipoprotein lipase (LPL) and catenin delta 2 (CTNND2) DNA methylation in peripheral white blood cells in non-diabetic young women. International journal of molecular sciences, 20(12), 2928.

Yang, X., Yao, B., Niu, Y., Chen, T., Mo, H., Wang, L., ... & Yao, D. (2019). Hypoxia-induced lncRNA EIF3J-AS1 accelerates hepatocellular carcinoma progression via targeting miR-122–5p/CTNND2 axis. Biochemical and Biophysical Research Communications, 518(2), 239-245.

van Rootselaar, A. F., Groffen, A. J., De Vries, B., Callenbach, P. M., Santen, G. W., Koelewijn, S., ... & Van Den Maagdenberg, A. M. (2017). δ-Catenin (CTNND2) missense mutation in familial cortical myoclonic tremor and epilepsy. Neurology, 89(23), 2341-2350.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-CTNND2 Recombinant Antibody (CBYCD-134)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-CTNND2 Recombinant Antibody (1E3) (CAT#: V2LY-0125-LY354)

Rabbit Anti-CTNND2 Recombinant Antibody (1009) (CAT#: V2LY-0125-LY352)

Mouse Anti-CTNND2 Recombinant Antibody (CBFYC-2417) (CAT#: V2LY-0125-LY355)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry