Mouse Anti-DAO Recombinant Antibody (2F5) (V2LY-0125-LY1082)

Name: Mouse Anti-DAO Recombinant Antibody (2F5)
SKU: V2LY-0125-LY1082
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2F5

Application

ELISA

Immunogen

DAO (119-219aa) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

D-Amino Acid Oxidase

Entrez Gene ID

1610

UniProt ID

P14920

Function

Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

Biological Process

Carboxylic acid metabolic process Source: Reactome
D-alanine catabolic process Source: UniProtKB
D-amino acid catabolic process Source: GO_Central
Dopamine biosynthetic process Source: UniProtKB
D-serine catabolic process Source: UniProtKB
D-serine metabolic process Source: UniProtKB
Proline catabolic process Source: UniProtKB
Protein localization Source: Reactome

Cellular Location

Peroxisome

Involvement in disease

Schizophrenia (SCZD):
A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

Padhi, A. K., & Hazra, S. (2019). Insights into the role of d‐amino acid oxidase mutations in amyotrophic lateral sclerosis. Journal of cellular biochemistry, 120(2), 2180-2197.

Nagano, T., Yamao, S., Terachi, A., Yarimizu, H., Itoh, H., Katasho, R., ... & Kamada, S. (2019). D-amino acid oxidase promotes cellular senescence via the production of reactive oxygen species. Life science alliance, 2(1).

Chen, Y. C., Chou, W. H., Tsou, H. H., Fang, C. P., Liu, T. H., Tsao, H. H., ... & Liu, Y. L. (2019). A post-hoc study of D-amino acid oxidase in blood as an Indicator of post-stroke dementia. Frontiers in neurology, 10, 402.

Sasabe, J., & Suzuki, M. (2018). Emerging role of d-amino acid metabolism in the innate defense. Frontiers in microbiology, 9, 933.

Kondori, N. R., Paul, P., Robbins, J. P., Liu, K., Hildyard, J. C., Wells, D. J., & De Belleroche, J. S. (2018). Focus on the role of D-serine and D-amino acid oxidase in amyotrophic lateral sclerosis/motor neuron disease (ALS). Frontiers in molecular biosciences, 5, 8.

Du, S., Wang, Y., Weatherly, C. A., Holden, K., & Armstrong, D. W. (2018). Variations of L-and D-amino acid levels in the brain of wild-type and mutant mice lacking D-amino acid oxidase activity. Analytical and bioanalytical chemistry, 410(12), 2971-2979.

Lin, H., Hu, H., Duan, W., Liu, Y., Tan, G., Li, Z., ... & Li, C. (2018). Intramuscular delivery of scAAV9-hIGF1 prolongs survival in the hSOD1G93A ALS mouse model via upregulation of D-amino acid oxidase. Molecular Neurobiology, 55(1), 682-695.

Jagannath, V., Marinova, Z., Monoranu, C. M., Walitza, S., & Grünblatt, E. (2017). Expression of D-amino acid oxidase (DAO/DAAO) and D-amino acid oxidase activator (DAOA/G72) during development and aging in the human post-mortem brain. Frontiers in neuroanatomy, 11, 31.

Lin, C. H., Yang, H. T., Chiu, C. C., & Lane, H. Y. (2017). Blood levels of D-amino acid oxidase vs. D-amino acids in reflecting cognitive aging. Scientific reports, 7(1), 1-10.

Koga, R., Miyoshi, Y., Sakaue, H., Hamase, K., & Konno, R. (2017). Mouse d-amino-acid oxidase: distribution and physiological substrates. Frontiers in molecular biosciences, 4, 82.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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