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Mouse Anti-DDX20 Recombinant Antibody (1C9F6) (CBMAB-D0538-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DEAD-Box Helicase 20 (DDX20). The antibody can be used for immunoassay techniques, such as ELISA, WB, ICC, IF, FC.
See all DDX20 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
1C9F6
Antibody Isotype
IgG1
Application
ELISA, WB, ICC, IF, FC

Basic Information

Immunogen
Recombinant fragment of human DDX20 expressed in E. Coli
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DEAD-Box Helicase 20
Introduction
DDX20 is a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. DDX20 interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.
Entrez Gene ID
Human11218
Rat84473
UniProt ID
HumanQ9UHI6
RatF1MAM8
Alternative Names
DEAD-Box Helicase 20; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 20, 103kD; DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 20; DEAD Box Protein DP 103; Component Of Gems 3; DEAD Box Protein 20; Gemin-3;
Function
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
Biological Process
Import into nucleus Source: Reactome
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of apoptotic process Source: MGI
RNA processing Source: ProtInc
Spliceosomal snRNP assembly Source: UniProtKB
Spliceosomal tri-snRNP complex assembly Source: ProtInc
Cellular Location
Gem; Cytoplasm. Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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