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Mouse Anti-ESRP1 Recombinant Antibody (CBFYE-1297) (CBMAB-E1893-FY)

This product is mouse antibody that recognizes ESRP1. The antibody CBFYE-1297 can be used for immunoassay techniques such as: ELISA, WB.
See all ESRP1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBFYE-1297
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to full length mouse Esrp-1 fusion protein
Specificity
Mouse
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.02M Potassium phosphate, 0.15M sodium chloride, pH 7.2
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Epithelial Splicing Regulatory Protein 1
Introduction
ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009).
Entrez Gene ID
207920
UniProt ID
Q3US41
Alternative Names
Rbm35a; BC031468; A630065D16; 2210008M09Rik
Research Area
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943).

Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity).
Biological Process
mRNA processing Source: UniProtKB-KW
Regulation of inner ear auditory receptor cell fate specification Source: UniProtKB
Regulation of RNA splicing Source: UniProtKB
RNA splicing Source: UniProtKB-KW
Cellular Location
Nucleus
Involvement in disease
Deafness, autosomal recessive, 109 (DFNB109):
A form of non-syndromic, sensorineural deafness characterized by bilateral, congenital, severe to profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB109 affected individuals additionally exhibit vestibular dysplasia, although they do not manifest problems with balance or movement.

Yu, L., Zhang, H., Guan, X., Qin, D., Zhou, J., & Wu, X. (2021). Loss of ESRP1 blocks mouse oocyte development and leads to female infertility. Development, 148(2), dev196931.

Zheng, M., Niu, Y., Bu, J., Liang, S., Zhang, Z., Liu, J., ... & Wang, Q. (2021). ESRP1 regulates alternative splicing of CARM1 to sensitize small cell lung cancer cells to chemotherapy by inhibiting TGF-β/Smad signaling. Aging (Albany NY), 13(3), 3554.

Yu, S., Wang, M., Zhang, H., Guo, X., & Qin, R. (2021). Circ_0092367 Inhibits EMT and Gemcitabine Resistance in Pancreatic Cancer via Regulating the miR-1206/ESRP1 Axis. Genes, 12(11), 1701.

Ashok, C., Ahuja, N., Natua, S., Mishra, J., Samaiya, A., & Shukla, S. (2021). E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression. Oncogenesis, 10(8), 1-10.

Deng, G., Zhou, X., Chen, L., Yao, Y., Li, J., Zhang, Y., ... & Tang, J. (2020). High expression of ESRP1 regulated by circ-0005585 promotes cell colonization in ovarian cancer. Cancer cell international, 20(1), 1-15.

Ahuja, N., Ashok, C., Natua, S., Pant, D., Cherian, A., Pandkar, M. R., ... & Shukla, S. (2020). Hypoxia-induced TGF-β–RBFOX2–ESRP1 axis regulates human MENA alternative splicing and promotes EMT in breast cancer. NAR cancer, 2(3), zcaa021.

Ala, U., Manco, M., Mandili, G., Tolosano, E., Novelli, F., Provero, P., ... & Fagoonee, S. (2020). Proteomics-based evidence for a pro-oncogenic role of ESRP1 in human colorectal cancer cells. International journal of molecular sciences, 21(2), 575.

Lee, S., Sears, M. J., Zhang, Z., Li, H., Salhab, I., Krebs, P., ... & Carstens, R. P. (2020). Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk. Development, 147(21), dev187369.

Gökmen‐Polar, Y., Neelamraju, Y., Goswami, C. P., Gu, Y., Gu, X., Nallamothu, G., ... & Badve, S. S. (2019). Splicing factor ESRP 1 controls ER‐positive breast cancer by altering metabolic pathways. EMBO reports, 20(2), e46078.

Gokmen-Polar, Y., Gu, Y., Gu, X., & Badve, S. S. (2019). Abstract P5-04-13: Splicing factor ESRP1 controls ER-positive breast cancer progression by altering metabolic pathway genes. Cancer Research, 79(4_Supplement), P5-04.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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