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  • Rat Anti-EXTL2 Recombinant Antibody (CBFYE-1421)

Rat Anti-EXTL2 Recombinant Antibody (CBFYE-1421) (V2LY-0825-LY983)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rat
Clone
CBFYE-1421
Application
WB
Immunogen
Recombinant mouse Exostosin-like 2/EXTL2 (Asn43-Met330).
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, trehalose
Preservative
None
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Exostosin Like Glycosyltransferase 2
Entrez Gene ID
58193
UniProt ID
Q9ES89
Research Area
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
Biological Process
Heparan sulfate proteoglycan biosynthetic process Source: UniProtKB-UniPathway
N-acetylglucosamine metabolic process Source: UniProtKB
Protein glycosylation Source: InterPro
UDP-N-acetylgalactosamine metabolic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Processed exostosin-like 2: Secreted. A soluble form is found in the serum.
Topology
Cytoplasmic: 1-22
Helical: 23-43
Lumenal: 44-330
PTM
The soluble form derives from the membrane form by proteolytic processing.

Marques, C., Poças, J., Gomes, C., Faria-Ramos, I., Reis, C. A., Vivès, R. R., & Magalhães, A. (2022). Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates Heparan Sulfate biosynthesis and shapes gastric cancer cell motility and invasion. Journal of Biological Chemistry, 102546.

Lei, J., Deng, H., Ran, Y., Lv, Y., Amhare, A. F., Wang, L., ... & Lammi, M. J. (2021). Altered expression of aggrecan, FAM20B, B3GALT6, and EXTL2 in patients with osteoarthritis and Kashin-beck disease. Cartilage, 13(1_suppl), 818S-828S.

Pu, A., Mishra, M. K., Dong, Y., Ghorbanigazar, S., Stephenson, E. L., Rawji, K. S., ... & Yong, V. W. (2020). The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination. Journal of Neuroinflammation, 17(1), 1-21.

Nadanaka, S., Hashiguchi, T., & Kitagawa, H. (2020). Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll‐like 4 receptor signaling. The FASEB Journal, 34(6), 8385-8401.

Pu, Y. (2019). The glycosyltransferase EXTL2 and its regulation of remyelination and neuroinflammation (Master's thesis, Cumming School of Medicine).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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