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Mouse Anti-FBXO2 Recombinant Antibody (CBXF-0395) (CBMAB-F0353-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0395
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
F-box protein 2
Introduction
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.
Entrez Gene ID
26232
UniProt ID
Q9UK22
Alternative Names
F-Box Protein 2; Organ Of Corti Protein 1; F-Box Only Protein 2; FBX2; F-Box Gene 1; NFB42; FBS1; FBG1; OCP1;
Research Area
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).
Biological Process
Cellular protein modification process Source: ProtInc
Glycoprotein catabolic process Source: UniProtKB
Negative regulation of cell population proliferation Source: Ensembl
Protein ubiquitination Source: UniProtKB
Proteolysis Source: ProtInc
Regulation of protein ubiquitination Source: Ensembl
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Ubiquitin-dependent ERAD pathway Source: GO_Central
Cellular Location
Cytoplasm; Microsome membrane
More Infomation

Ji, J., Shen, J., Xu, Y., Xie, M., Qian, Q., Qiu, T., ... & Liu, B. (2022). FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development. Cell death & disease, 13(5), 1-9.

Buehler, M., Yi, X., Ge, W., Blattmann, P., Rushing, E., Reifenberger, G., ... & Weiss, T. (2022). Quantitative proteomic landscapes of primary and recurrent glioblastoma reveal a protumorigeneic role for FBXO2-dependent glioma-microenvironment interactions. Neuro-oncology.

Yamada, A., Hikichi, M., Nozawa, T., & Nakagawa, I. (2021). FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan. EMBO reports, 22(11), e52584.

Wong, S. Y., Lu, P., Wu, L., Montgomery, M., Chowanadisai, W., Lucas, E., ... & Lin, D. (2020). Hepatic F-box Only Protein 2 (FBXO2) Might Not Mediate Glucose Homeostasis in Obese Diabetic Mice. Current Developments in Nutrition, 4(Supplement_2), 1281-1281.

Liu, E. A., Schultz, M. L., Mochida, C., Chung, C., Paulson, H. L., & Lieberman, A. P. (2020). Fbxo2 mediates clearance of damaged lysosomes and modifies neurodegeneration in the Niemann-Pick C brain. JCI insight, 5(20).

Che, X., Jian, F., Wang, Y., Zhang, J., Shen, J., Cheng, Q., ... & Feng, W. (2020). FBXO2 promotes proliferation of endometrial cancer by ubiquitin-mediated degradation of FBN1 in the regulation of the cell cycle and the autophagy pathway. Frontiers in cell and developmental biology, 8, 843.

Zhao, X., Guo, W., Zou, L., & Hu, B. (2020). FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells. Cancer cell international, 20(1), 1-9.

Wei, X., Bu, J., Mo, X., Lv, B., Wang, X., & Hou, B. (2018). The prognostic significance of FBXO2 expression in colorectal cancer. International Journal of Clinical and Experimental Pathology, 11(10), 5054.

Zhang, H. J., Tian, J., Qi, X. K., Xiang, T., He, G. P., Zhang, H., ... & Feng, L. (2018). Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation. PLoS pathogens, 14(7), e1007208.

Sun, X., Wang, T., Guan, Z. R., Zhang, C., Chen, Y., Jin, J., & Hua, D. (2018). FBXO2, a novel marker for metastasis in human gastric cancer. Biochemical and biophysical research communications, 495(3), 2158-2164.

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For research use only. Not intended for any clinical use.

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