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Rabbit Anti-FCGR2B Recombinant Antibody (046) (CBMAB-C1765-LY)

This product is antibody recognizes FCGR2B. The antibody 046 immunoassay techniques such as: ELISA.
See all FCGR2B antibodies

Summary

Host Animal
Rabbit
Specificity
Monkey
Clone
046
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Cynomolgus CD32b / Fc gamma RIIB protein
Specificity
Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fc receptor, IgG, low affinity Iib
Introduction
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Entrez Gene ID
UniProt ID
Research Area
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: ARUK-UCL
Cell surface receptor signaling pathway Source: GO_Central
Cellular response to amyloid-beta Source: ARUK-UCL
Cellular response to molecule of bacterial origin Source: ARUK-UCL
Cerebellum development Source: BHF-UCL
Defense response Source: ARUK-UCL
Fc-gamma receptor signaling pathway involved in phagocytosis Source: ARUK-UCL
Follicular B cell differentiation Source: ARUK-UCL
Follicular dendritic cell activation Source: ARUK-UCL
Immune complex clearance by monocytes and macrophages Source: ARUK-UCL
Immune response Source: ProtInc
Immunoglobulin mediated immune response Source: ARUK-UCL
Inflammatory response Source: ARUK-UCL
Mature B cell differentiation involved in immune response Source: ARUK-UCL
Negative regulation of acute inflammatory response to antigenic stimulus Source: ARUK-UCL
Negative regulation of antibody-dependent cellular cytotoxicity Source: ARUK-UCL
Negative regulation of B cell activation Source: ARUK-UCL
Negative regulation of B cell proliferation Source: ARUK-UCL
Negative regulation of B cell receptor signaling pathway Source: ARUK-UCL
Negative regulation of cytokine production Source: ARUK-UCL
Negative regulation of cytotoxic T cell degranulation Source: ARUK-UCL
Negative regulation of dendritic cell antigen processing and presentation Source: ARUK-UCL
Negative regulation of dendritic cell differentiation Source: ARUK-UCL
Negative regulation of humoral immune response mediated by circulating immunoglobulin Source: ARUK-UCL
Negative regulation of immune response Source: ARUK-UCL
Negative regulation of immunoglobulin production Source: ARUK-UCL
Negative regulation of interleukin-10 production Source: ARUK-UCL
Negative regulation of macrophage activation Source: ARUK-UCL
Negative regulation of neutrophil activation Source: ARUK-UCL
Negative regulation of phagocytosis Source: ARUK-UCL
Negative regulation of type I hypersensitivity Source: ARUK-UCL
Phagocytosis, engulfment Source: ARUK-UCL
Positive regulation of humoral immune response Source: ARUK-UCL
Positive regulation of JNK cascade Source: BHF-UCL
Positive regulation of neuron death Source: BHF-UCL
Positive regulation of phagocytosis Source: ARUK-UCL
Positive regulation of response to endoplasmic reticulum stress Source: ARUK-UCL
Receptor-mediated endocytosis Source: ARUK-UCL
Regulation of adaptive immune response Source: ARUK-UCL
Regulation of B cell antigen processing and presentation Source: ARUK-UCL
Regulation of dendritic spine maintenance Source: ARUK-UCL
Regulation of immune complex clearance by monocytes and macrophages Source: ARUK-UCL
Regulation of immune response Source: GO_Central
Regulation of innate immune response Source: ARUK-UCL
Regulation of signaling receptor activity Source: ARUK-UCL
Response to bacterium Source: ARUK-UCL
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
Involvement in disease
Systemic lupus erythematosus (SLE):
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Topology
Extracellular: 43-217
Helical: 218-240
Cytoplasmic: 241-310
PTM
Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.

Li, Q., Zhong, J., Luo, H., Urbonaviciute, V., Xu, Z., He, C., & Holmdahl, R. (2022). Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance. Cellular and Molecular Life Sciences, 79(9), 1-17.

Saisorn, W., Saithong, S., Phuengmaung, P., Udompornpitak, K., Bhunyakarnjanarat, T., Visitchanakun, P., ... & Leelahavanichkul, A. (2021). Acute kidney injury induced lupus exacerbation through the enhanced neutrophil extracellular traps (and apoptosis) in Fcgr2b deficient lupus mice with renal ischemia reperfusion injury. Frontiers in immunology, 12, 2336.

Nowicka, M., Hilton, L. K., Ashton-Key, M., Hargreaves, C. E., Lee, C., Foxall, R., ... & Cragg, M. S. (2021). Prognostic significance of FCGR2B expression for the response of DLBCL patients to rituximab or obinutuzumab treatment. Blood advances, 5(15), 2945-2957.

Daprá, V., Giraudo, I., Zaniol, E., Galliano, I., Calvi, C., Montanari, P., ... & Bergallo, M. (2021). Evaluation of the FCGR2B polymorphism in children with immune thrombocytopenia. Minerva Pediatrics.

Cheng, Q., Chen, Y., Dai, Z., Zeng, W., Wen, Z., Zhang, H., ... & Chen, X. P. (2020). Integrative Molecular and Immune Characterization of FCGR2B in Glioma. Available at SSRN 3566099.

Chen, Y., Chen, C., Shih, J., Yu, C., & Yang, P. (2019). P2. 04-34 FCGR2B Expression as a Regulator of Immunity in Non-Small Cell Lung Cancer Patients. Journal of Thoracic Oncology, 14(10), S721-S722.

Strefford, J. C., Nowicka, M., Hargreaves, C., Iriyama, C., Latham, K. V., Ganderton, R., ... & Oestergaard, M. Z. (2018). Prognostic impact of germ-line FCGR2A (H131R), FCGR3A (F158V), and FCGR2B (I232T) single nucleotide polymorphisms in lymphoma patients treated with obinutuzumab or rituximab in combination with chemotherapy: results from the phase III GALLIUM and GOYA clinical trials. Blood, 132, 4109.

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For research use only. Not intended for any clinical use.

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