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Mouse Anti-FGF15 Recombinant Antibody (CBXF-1740) (CBMAB-F3275-CQ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBXF-1740
Application
WB, IP, IF, ELISA
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
fibroblast growth factor 15
Entrez Gene ID
14170
UniProt ID
O35622
Alternative Names
FGF19
Research Area
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.
Biological Process
Animal organ morphogenesis Source: GO_Central
Bile acid and bile salt transport Source: Ensembl
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Heart development Source: MGI
Negative regulation of bile acid biosynthetic process Source: MGI
Negative regulation of gene expression Source: MGI
Neural crest cell migration Source: MGI
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: MGI
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: MGI
Positive regulation of JNK cascade Source: MGI
Positive regulation of protein phosphorylation Source: MGI
Regulation of cell migration Source: GO_Central
Response to bacterium Source: MGI
Response to ethanol Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Cellular Location
Secreted

Rizzolo, D., Kong, B., Piekos, S., Chen, L., Zhong, X., Lu, J., ... & Guo, G. L. (2022). Effects of Overexpression of Fibroblast Growth Factor 15/19 on Hepatic Drug Metabolizing Enzymes. Drug Metabolism and Disposition, 50(4), 468-477.

Kong, B., Huang, M., Taylor, R. E., Rizzolo, D., Otersen, K. D., & Guo, G. L. (2022). Effects of intestine-specific deletion of fibroblast growth factor 15 on alcoholic liver disease development in mice. Liver Research.

Maliha, S., & Guo, G. L. (2021). Farnesoid X receptor and fibroblast growth factor 15/19 as pharmacological targets. Liver Research, 5(3), 142-150.

Schumacher, J. D., Kong, B. O., Wu, J., Rizzolo, D., Armstrong, L. E., Chow, M. D., ... & Guo, G. L. (2020). Direct and indirect effects of fibroblast growth factor (FGF) 15 and FGF19 on liver fibrosis development. Hepatology, 71(2), 670-685.

Avalos-de León, C. G., Jiménez-Castro, M. B., Cornide-Petronio, M. E., Gulfo, J., Rotondo, F., Gracia-Sancho, J., ... & Peralta, C. (2019). The effect of fibroblast growth factor 15 signaling in non-steatotic and steatotic liver transplantation from cardiocirculatory death. Cells, 8(12), 1640.

Gadaleta, R. M., & Moschetta, A. (2019). Metabolic Messengers: fibroblast growth factor 15/19. Nature Metabolism, 1(6), 588-594.

Kong, B., Sun, R., Huang, M., Chow, M. D., Zhong, X. B., Xie, W., ... & Guo, G. L. (2018). Fibroblast growth factor 15–dependent and bile acid–independent promotion of liver regeneration in mice. Hepatology, 68(5), 1961-1976.

Hartmann, P., Hochrath, K., Horvath, A., Chen, P., Seebauer, C. T., Llorente, C., ... & Schnabl, B. (2018). Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology, 67(6), 2150-2166.

Somm, E., & Jornayvaz, F. R. (2018). Fibroblast growth factor 15/19: from basic functions to therapeutic perspectives. Endocrine reviews, 39(6), 960-989.

Metry, M., Felton, J., Cheng, K., Xu, S., Ai, Y., Xue, F., ... & Polli, J. E. (2018). Attenuated accumulation of novel fluorine (19F)-labeled bile acid analogues in gallbladders of fibroblast growth factor-15 (FGF15)-deficient mice. Molecular pharmaceutics, 15(11), 4827-4834.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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