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Mouse Anti-FGF9 Recombinant Antibody (CBXF-1744) (CBMAB-F3279-CQ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBXF-1744
Application
WB, IP, IF, ELISA
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Fibroblast Growth Factor 9
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis.
Entrez Gene ID
Human2254
Mouse14180
Rat25444
UniProt ID
HumanP31371
MouseP54130
RatP36364
Alternative Names
Fibroblast Growth Factor 9; Fibroblast Growth Factor 9 (Glia-Activating Factor); Heparin-Binding Growth Factor 9; Glia-Activating Factor; HBGF-9; FGF-9; GAF; HBFG-9; SYNS3;
Research Area
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Lung development Source: GO_Central
Male gonad development Source: UniProtKB
Negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Source: BHF-UCL
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of epithelial cell proliferation Source: GO_Central
Positive regulation of gene expression Source: GO_Central
Positive regulation of MAPK cascade Source: Ensembl
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of vascular associated smooth muscle cell migration Source: BHF-UCL
Positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Regulation of cell migration Source: GO_Central
Signal transduction Source: ProtInc
Substantia nigra development Source: UniProtKB
Cellular Location
Secreted
Involvement in disease
Multiple synostoses syndrome 3 (SYNS3):
A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism.
PTM
Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step.
N-glycosylated.

Li, A., Tian, J., Yang, J., Ren, X., Zhou, Z., & Zhou, W. (2021). Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats. Neuroreport, 32(4), 321-325.

Yusuf, I. O., Chen, H. M., Cheng, P. H., Chang, C. Y., Tsai, S. J., Chuang, J. I., ... & Yang, S. H. (2021). Fibroblast growth factor 9 stimulates neuronal length through NF-kB signaling in striatal cell Huntington’s disease models. Molecular Neurobiology, 58(5), 2396-2406.

Zhang, X., Weng, M., & Chen, Z. (2021). Fibroblast Growth Factor 9 (FGF9) negatively regulates the early stage of chondrogenic differentiation. Plos One, 16(2), e0241281.

Huang, K., Wang, Y., Zhu, J., Xiong, Y., & Lin, Y. (2021). Regulation of fibroblast growth factor 9 on the differentiation of goat intramuscular adipocytes. Animal Science Journal, 92(1), e13627.

Rejali, L., Seyedna, S. Y., Aghdaei, H. A., Mojarad, E. N., & Hashemi, M. (2021). Fibroblast growth factor 9 correlation with lymphatic and vascular invasion in colorectal cancer. International Journal of Cancer Management, 14(2).

Gao, X., Zhu, M., An, S., Liang, Y., Yang, H., Pang, J., ... & Wang, F. (2020). Long non-coding RNA LOC105611671 modulates fibroblast growth factor 9 (FGF9) expression by targeting oar-miR-26a to promote testosterone biosynthesis in Hu sheep. Reproduction, Fertility and Development, 32(4), 373-382.

Seitz, T., Freese, K., Dietrich, P., Thasler, W. E., Bosserhoff, A., & Hellerbrand, C. (2020). Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma. Scientific reports, 10(1), 1-9.

Huang, J., Wang, K., Shiflett, L. A., Brotto, L., Bonewald, L. F., Wacker, M. J., ... & Brotto, M. (2019). Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells. Cell Cycle, 18(24), 3562-3580.

Yusuf, I. O., Cheng, P. H., Chen, H. M., Chang, Y. F., Chang, C. Y., Yang, H. I., ... & Yang, S. H. (2018). Fibroblast growth factor 9 suppresses striatal cell death dominantly through ERK signaling in Huntington’s disease. Cellular Physiology and Biochemistry, 48(2), 605-617.

He, X., Chen, S. Y., Yang, Z., Zhang, J., Wang, W., Liu, M. Y., ... & Sun, G. G. (2018). miR-4317 suppresses non-small cell lung cancer (NSCLC) by targeting fibroblast growth factor 9 (FGF9) and cyclin D2 (CCND2). Journal of Experimental & Clinical Cancer Research, 37(1), 1-16.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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