Mouse Anti-FGGY Recombinant Antibody (CBXF-0640) (V2LY-0925-LY1817)

Name: Mouse Anti-FGGY Recombinant Antibody (CBXF-0640)
SKU: V2LY-0925-LY1817
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0640

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 1-300 mapping at the N-terminus of human FGGY.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

FGGY Carbohydrate Kinase Domain Containing

Entrez Gene ID

55277

UniProt ID

Q96C11

Function

Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency.

Biological Process

Carbohydrate phosphorylation Source: UniProtKB
Neuron cellular homeostasis Source: UniProtKB
Pentose metabolic process Source: SGD

Involvement in disease

Amyotrophic lateral sclerosis (ALS):
A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.

Smith, A. L., Gjoka, E., Izhar, M., Novo, K. J., Mason, B. C., De Las Casas, A., & Waddell, D. S. (2021). FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling. Gene, 800, 145836.

Smith, A., Izhar, M., Gjoka, E., Novo, K., & Waddell PhD, D. (2020). Fggy Carbohydrate Kinase Domain Containing is Induced During Skeletal Muscle Atrophy and Regulates MAP Kinase Signaling.

Izhar, M., Smith, A., & Waddell, D. (2019). FGGY Carbohydrate Kinase Domain Containing (Fggy) is Expressed and Alternatively Spliced in Skeletal Muscle. The FASEB Journal, 33(S1), 700-16.

Taylor, J. A., Shioda, K., Mitsunaga, S., Yawata, S., Angle, B. M., Nagel, S. C., ... & Shioda, T. (2018). Prenatal exposure to bisphenol A disrupts naturally occurring bimodal DNA methylation at proximal promoter of fggy, an obesity-relevant gene encoding a carbohydrate kinase, in gonadal white adipose tissues of CD-1 mice. Endocrinology, 159(2), 779-794.

Novo, K., & Waddell, D. (2018). Identification and Characterization of FGGY Carbohydrate Kinase Domain Containing (Fggy) in Skeletal Muscle. The FASEB Journal, 32, 856-21.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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