Mouse Anti-FHL5 Recombinant Antibody (CBXF-1414) (CBMAB-F2365-CQ)

Name: Mouse Anti-FHL5 Recombinant Antibody (CBXF-1414)
SKU: CBMAB-F2365-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-1414

Application

ELISA, ICC, WB

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

four and a half LIM domains 5

Introduction

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein.

Entrez Gene ID

9457

UniProt ID

Q5TD97

Alternative Names

Four And A Half LIM Domains 5; Activator Of CAMP-Responsive Element Modulator In Testis; FHL-5; ACT; Activator Of CAMP-Responsive Element Modulator (CREM) In Testis; Four And A Half LIM Domains Protein 5;

Function

May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.

Biological Process

Positive regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus. Nuclei of round and elongated spermatids.

Wong, D., Auguste, G. E., Turner, A., Palmore, M., Perry, N., Aherrahrou, R., ... & Miller, C. (2022). Fhl5 Enhances Vascular Calcification By Regulating Smooth Muscle Cell Transcriptional Networks. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(Suppl_1), A466-A466.

Wong, D., Auguste, G., Cardenas, C. L. L., Turner, A. W., Chen, Y., Ma, L., ... & Miller, C. L. (2022). FHL5 controls vascular disease-associated gene programs in smooth muscle cells. bioRxiv.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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