Mouse Anti-FKBP6 Recombinant Antibody (CBXF-3055) (V2LY-0925-LY2106)

Name: Mouse Anti-FKBP6 Recombinant Antibody (CBXF-3055)
SKU: V2LY-0925-LY2106
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-3055

Application

WB, IP, ELISA

Immunogen

Amino acids 1-108 representing partial length of human FKBP6.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium azide

Concentration

0.1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

FK506 Binding Protein 6

Entrez Gene ID

8468

UniProt ID

O75344

Function

Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
DNA methylation involved in gamete generation Source: UniProtKB
Gene silencing by RNA Source: UniProtKB
Meiotic cell cycle Source: UniProtKB
piRNA metabolic process Source: UniProtKB
Positive regulation of viral genome replication Source: AgBase
Protein folding Source: UniProtKB
Protein peptidyl-prolyl isomerization Source: GOC
Spermatogenesis Source: UniProtKB

Cellular Location

Cytosol; Nucleus; Chromosome. Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity).

Involvement in disease

FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease (PubMed:9782077). A father and son with Williams-Beuren syndrome appear to have a common heterozygous deletion that includes FKBP6 gene. However, the haploinsufficiency for FKBP6 does not appear to preclude male fertility (PubMed:15770126).
Defects in FKBP6 may be a cause of azoospermia. A study based on 323 patients with azoospermia or severe oligozoospermia suggested an association between FKBP6 variants and azoospermia (PubMed:17307919). However, other studies suggest that defects in FKBP6 are not a common cause of non-obstructive azoospermia (PubMed:16227348).

Wyrwoll, M. J., Gaasbeek, C. M., Golubickaite, I., Stakaitis, R., Oud, M. S., Nagirnaja, L., ... & van der Heijden, G. W. (2022). The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans. The American Journal of Human Genetics, 109(10), 1850-1866.

Castaneda, C., Juras, R., Kjöllerström, J., Hernandez Aviles, C., Teague, S. R., Love, C. C., ... & Raudsepp, T. (2021). Thoroughbred stallion fertility is significantly associated with FKBP6 genotype but not with inbreeding or the contribution of a leading sire. Animal Genetics, 52(6), 813-823.

Vilariño-Güell, C., Encarnacion, M., Bernales, C. Q., & Sadovnick, A. D. (2019). Analysis of Canadian multiple sclerosis patients does not support a role for FKBP6 in disease. Multiple Sclerosis Journal, 25(7), 1011-1013.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-FKBP6 Recombinant Antibody (CBXF-1752) (CAT#: CBMAB-F3287-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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